Ultra fast liquid chromatographic analysis of nonsteroidal anti-inflammatory drugs with fluorimetric detection in tap water, urine, and pharmaceutical samples

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dc.authorid0000-0002-5840-7386en_US
dc.authorscopusid6701367993en_US
dc.authorwosidD-5195-2014en_US
dc.authorwosidFZV-5400-2022en_US
dc.contributor.authorÖnal, Cem
dc.contributor.authorTırıs, Gizem
dc.contributor.authorKepekçi Tekkeli, Şerife Evrim
dc.contributor.authorÖnal, Armağan
dc.date.accessioned2022-06-11T15:10:37Z
dc.date.available2022-06-11T15:10:37Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractA novel analytical method based on ultra-fast liquid chromatography using fluorimetric detector was developed and validated for determination of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen (IBP), etodolac (ETD), dexketoprofen (DKP), sodium diclofenac (SDCF), and naproxen (NPX) in tap water, urine and pharmaceutical samples. Precolumn derivatisation of targeted NSAIDs was carried out with 4-bromomethyl-7-methoxy coumarin (BrMmC) using dibenzo-18-crown-6-ether as reaction catalyst leading to the formation of a fluorescent compound. The obtained fluorescent compound of NSAIDs were measured at excitation wavelength as 325 nm, and emission wavelength of 395 nm. Optimum analytical conditions were carefully studied and improved. C18 column, with the dimensions of 4.0 × 100 mm and 3 µm particle size, was used. Gradient elution with methanol: water 40:60; v/v (eluent A) and acetonitrile 100% (eluent B) were used as mobile phase and flow rate of 0.4 mL/min. The linearity range of the analytes were between 0.01–10.0 µg mL−1. Recovery values obtained from pharmaceutical preparations were found as 100.04%, 99.99%, 100.09%, 99.98% and 100.47% for IBP, ETO, DKP, SDCF, NPX, respectively. LOD values were found to vary between 0.00009 µg mL−1 and 0.00048 µg mL−1 in tap water, urine and pharmaceutical samples. The optimised technique was successfully applied for the determination of NSAIDs in tap water, urine, and pharmaceutical specimen. The specified NSAIDs were not found in real tap water samples.en_US
dc.identifier.citationÖnal, C., Tırıs, G., Kepekçi Tekkeli, S. E., & Önal, A. (2024). Ultra fast liquid chromatographic analysis of nonsteroidal anti-inflammatory drugs with fluorimetric detection in tap water, urine, and pharmaceutical samples. International Journal of Environmental Analytical Chemistry, 104(12), 2823-2833. https://doi.org/10.1080/03067319.2022.2071614en_US
dc.identifier.doi10.1080/03067319.2022.2071614en_US
dc.identifier.endpage2833en_US
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85131540738en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2823en_US
dc.identifier.urihttps://doi.org/10.1080/03067319.2022.2071614
dc.identifier.urihttps://hdl.handle.net/20.500.13055/227
dc.identifier.volume104en_US
dc.identifier.wosWOS:000807010100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖnal, Cem
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofInternational Journal of Environmental Analytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectUltra fast liquid chromatographyen_US
dc.subjectFluorescence detectionen_US
dc.subject4-bromomethyl-7-methoxy coumarinen_US
dc.subjectUrineen_US
dc.subjectPharmaceutical preparationen_US
dc.subjectTap wateren_US
dc.titleUltra fast liquid chromatographic analysis of nonsteroidal anti-inflammatory drugs with fluorimetric detection in tap water, urine, and pharmaceutical samplesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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