Spray-assisted drop formation liquid-phase microextraction for the determination of sertraline in environmental water samples with matrix-matching calibration in GC–MS

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dc.authorid0000-0002-4624-6212
dc.authorid0000-0001-5053-4156
dc.authorid0000-0003-0542-1050
dc.authorid0000-0002-8129-7488
dc.authorid0000-0003-0745-6863
dc.authorid0000-0001-9746-3682
dc.contributor.authorZeytinci, Nagehan Kübra
dc.contributor.authorAkbıyık, Hilal
dc.contributor.authorTezgin, Emine
dc.contributor.authorZaman, Buse Tuğba
dc.contributor.authorDalgıç Bozyiğit, Gamze
dc.contributor.authorŞaylan, Meltem
dc.contributor.authorBakırdere, Sezgin
dc.date.accessioned2024-08-14T11:42:43Z
dc.date.available2024-08-14T11:42:43Z
dc.date.issued2024
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractSertraline is used as an antidepressant drug for the treatment of psychiatric disorders, including anxiety and depres sion. In the current study, a simple and efective method was developed for the sensitive monitoring of sertraline in water samples using a GC–MS system. The spray-assisted droplet formation liquid-phase microextraction (SADF LPME) method was used as a sample preparation method for the enrichment of analytes. Accordingly, dichlo romethane was used as an extraction solvent and easily dispersed into a sample/standard solution using a lab-made modifed spray device without using a dispersing solvent. The signifcant factors afecting the SADF-LPME efciency, including sample pH, mixing conditions, extraction solvent type, and spray cycle, were univariately optimized to ascertain the extraction performance and applicability of the system. Under the optimized conditions, the plotted calibration curve of the method was linear in the range of 100.2–2011.7 µg/kg (mass-based standard preparation) with a good correlation coefcient (R2 ) of 0.9997. The detection and quantifcation limits of method were found to be 37.5 and 125 µg/kg, respectively. Validation of the method was successfully carried out using diferent tap water samples and applying a matrix-matching calibration strategy. The acceptable percent recoveries were recorded between 77.3 and 133.7%, with high repeatability. The recommended method is an alternative and fast extraction method with several advantages, including a simple experimental process, good dispersibility, and fast and superior extraction performance. It can be readily applicable to the monitoring and quantifcation of sertraline in tap water samples with good precision and accuracy.
dc.identifier.citationZeytinci, N. K., Akbıyık, H., Tezgin, E., Zaman, B. T., Dalgıç Bozyiğit, G., Şaylan, M., & Bakırdere, S. (2024). Spray-assisted drop formation liquid-phase microextraction for the determination of sertraline in environmental water samples with matrix-matching calibration in GC–MS. Journal of Analytical Science and Technology, 15(1), pp. 1-9. https://doi.org/10.1186/s40543-024-00459-9 en_US
dc.identifier.doi10.1186/s40543-024-00459-9
dc.identifier.endpage9
dc.identifier.issn2093-3134
dc.identifier.issn2093-3371
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85200830694en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1186/s40543-024-00459-9
dc.identifier.urihttps://hdl.handle.net/20.500.13055/749
dc.identifier.volume15
dc.identifier.wosWOS:001288281600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorŞaylan, Meltem
dc.institutionauthorid0000-0003-0745-6863
dc.language.isoen
dc.publisherSpringerOpen
dc.relation.ispartofJournal of Analytical Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitak1919B012209338
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSertraline
dc.subjectGas Chromatography
dc.subjectTap Water
dc.subjectMatrix-Matching Calibration
dc.subjectMicroextraction
dc.titleSpray-assisted drop formation liquid-phase microextraction for the determination of sertraline in environmental water samples with matrix-matching calibration in GC–MS
dc.typeArticle
dspace.entity.typePublication

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