Anatomical and functional alterations in juvenile myoclonic epilepsy: voxel-based morphometry and resting-state fMRI study

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dc.authorid0000-0001-7507-1696en_US
dc.authorscopusid57170770100en_US
dc.authorwosidDKB-0030-2022en_US
dc.contributor.authorUr Özçelik, Emel
dc.contributor.authorAy, Ulaş
dc.contributor.authorKurt, Erkan
dc.contributor.authorŞirin, Nermin Görkem
dc.contributor.authorBebek, Nerses
dc.contributor.authorDemiralp, Tuğba
dc.contributor.authorBaykan, Betül
dc.date.accessioned2023-01-02T11:28:16Z
dc.date.available2023-01-02T11:28:16Z
dc.date.issued2022en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümüen_US
dc.description.abstractPurpose: We aimed to investigate the structural and functional brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity. Methods: Thirty JME patients, 15 of (50%) who were photosensitive (JME-PS) and 32 healthy controls (HC) were involved in the study. The high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state functional MRI data were acquired for functional connectivity (FC) analysis. The regions that showed significant differences in VBM analyses, were used as regions of interest in FC analysis for the comparisons between the whole JME group, which consist of PS and non-photosensitive (NPS) JME subgroups, and HCs. Cluster-level significance was set at family-wise error (FWE) corrected p < 0.05. Results: The left postcentral gyrus showed decreased connectivity in the right dominant bilateral middle cingulate gyrus, the right dominant bilateral supplementary motor area, and right superior frontal gyrus whereas left cerebellum crus 1 showed decreased connectivity in right cerebellum lobule IX and dorsal pons in JME-PS compared to the HCs (pFWE-corr = 0.0014, pFWE-corr = 0.0436,respectively).The left middle temporal gyrus showed decreased connectivity with the left dominant bilateral superior frontal gyrus in JME-PS compared to JME-NPS (pFWE-corr = 0.0016). Left precentral gyrus showed; i) increased connectivity with left superior frontal gyrus in JME-NPS compared to HCs (pFWE-corr = 0.0015), ii) decreased connectivity with right dominant bilateral calcarine fissure and occipital pole in JME-PS compared to JME-NPS (pFWE-corr = 0.0103).en_US
dc.identifier.citationUr Özçelik, E., Ay, U., Kurt, E., Şirin, N. G., Bebek, N., Demiralp, T. & Baykan, B. (2022). Anatomical and functional alterations in juvenile myoclonic epilepsy: voxel-based morphometry and resting-state fMRI study. Epilepsia, 63(Supplement: 2), 214-215.en_US
dc.identifier.endpage215en_US
dc.identifier.issn0013-9580
dc.identifier.issn1528-1167
dc.identifier.issueSupplement: 2en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://hdl.handle.net/20.500.13055/355
dc.identifier.volume63en_US
dc.identifier.wosWOS:000854255900415en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorUr Özçelik, Emel
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEpilepsiaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectJuvenile Myoclonic Epilepsyen_US
dc.subjectAnatomicalen_US
dc.subjectFunctional Alterationen_US
dc.subjectVoxel-Based Morphometryen_US
dc.subjectfMRIen_US
dc.titleAnatomical and functional alterations in juvenile myoclonic epilepsy: voxel-based morphometry and resting-state fMRI studyen_US
dc.typeConference Objecten_US
dspace.entity.typePublication

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