Role of chemokines in early pregnancy loss

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorGökçe, Şefik
dc.contributor.authorHerkiloğlu, Dilşad
dc.contributor.authorÇevik, Özge
dc.contributor.authorTuran, Volkan
dc.date.accessioned2022-05-17T13:28:30Z
dc.date.available2022-05-17T13:28:30Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractThe present study aimed to compare decidual protein levels and gene expression levels of chemokines between patients with early pregnancy loss and those with voluntary abortion. A total of 15 patients between 6 and 10 gestational weeks, who presented with negative fetal heartbeat to the obstetrics and gynecology outpatient clinics of Gaziosmanpasa Hospital (Yeni Yuzyil University, Istanbul, Turkey) and who had no additional systemic disease and 13 patients between 6 and 10 gestational weeks, who presented with positive fetal heartbeat for voluntary abortion were included in the present study. CX3CL1, CCL17, CXCR4, chemokine ligand 12 (CXCL12) and intercellular adhesion molecule (ICAM)5 protein expression levels were determined by ELISA and gene expression levels by reverse transcription-quantitative PCR in fresh materials recovered after therapeutic curettage. CX3CL1, CCL17, CXCR4, CXCL12 protein levels were significantly higher and ICAM protein level was significantly lower in pregrant women with missed abortion compared with those with voluntary abortion. While the amount of increase in mean CX3CL1, CCL17, CXCR4 and CXCL12 gene expression levels in the tissues of pregnant women with missed abortion was statistically higher than the pregnant women who underwent voluntary abortion, the amount of increase in ICAM5 gene expression was found to be lower (P<0.001) in those with missed abortion. In conclusion, the findings of the present study suggested that CCL17, CX3CL1, CXCL12, CXCR4 and ICAM5 may be associated with missed abortion and may play an important role in placental invasion and the continuation of pregnancy.en_US
dc.identifier.citationGokce, S., Herkiloglu, D., Cevik, O., & Turan, V. (2022). Role of chemokines in early pregnancy loss. Experimental and therapeutic medicine, 23(6), 397. https://doi.org/10.3892/etm.2022.11324en_US
dc.identifier.doi10.3892/etm.2022.11324en_US
dc.identifier.endpage7en_US
dc.identifier.issue6en_US
dc.identifier.pmidPMID: 35495608en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3892/etm.2022.11324
dc.identifier.urihttps://hdl.handle.net/20.500.13055/216
dc.identifier.volume23en_US
dc.identifier.wosWOS:000798383200001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherSpandidos Publicationsen_US
dc.relation.ispartofExperimental and Therapeutic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCCL17en_US
dc.subjectCX3CL1en_US
dc.subjectCXCR4en_US
dc.subjectChemokine ligand 12en_US
dc.subjectIntercellular adhesion moleculeen_US
dc.titleRole of chemokines in early pregnancy lossen_US
dc.typeArticleen_US
dspace.entity.typePublication

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