Is chromosomal radiosensitivity a predictive tool for cancer risks?

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dc.authorscopusid55915512200en_US
dc.authorwosidJ-5441-2018en_US
dc.contributor.authorKolusayın Ozar, Melek Özlem
dc.contributor.authorOrta, Tuncay
dc.contributor.authorDizdar, Yavuz
dc.contributor.authorKaytan Sağlam, Esra
dc.contributor.authorSağlam, Sezer
dc.contributor.authorTurna, Akif
dc.contributor.authorOkutan, Murat
dc.contributor.authorDemirci, Sibel
dc.contributor.authorOzar, Engin
dc.contributor.authorDaştan, Kadir
dc.contributor.authorYükseloğlu, Emel Hülya
dc.date.accessioned2021-12-22T08:09:15Z
dc.date.available2021-12-22T08:09:15Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Adli Tıp Ana Bilim Dalıen_US
dc.description.abstractThere is an extensive landscape of genomic disruptions caused by environmental carcinogens. A major environmental mutagen that can trigger direct changes in the DNA is radiation. In certain places, ionizing radiation such as X-rays can break DNA sequences leading to chromosome rearrangements. Prediction of cancer risk is an important phenomenon in the early diagnosis of cancer. Early diagnosis will lead to the most economical treatment protocols, thus decreasing the mortality and morbidity rates. Chromosome aberrations and radiosensitivity have been shown to be biological indicators of cancer predisposition. Four different types of cancers [breast, lung, prostate and colon] were examined in this study to see the indicator role of chromosome radio sensitivity in predicting cancer. We measured chromosome aberrations before and after giving 2 Gy radiation in peripheral blood lymphocyte samples of four cancer groups each consisted of 30 newly diagnosed patients and their matched healthy individuals summed up to total of 180 individual donors. Acentric, dicentric and ring chromosome aberrations were scored before and after irradiation for each donor. Absolute chromosome frequencies were calculated by subtracting spontaneous frequencies from 2 Gy irradiated values. Dicentrics as being primer indicator of radiation and total chromosome aberrations were evaluated for each group to predict effectiveness of chromosomal radiosensitivity. Our results show that the chromosomal radiosensitivity might predict cancer risk for prostate and lung cancer patient groups, but not for breast and colon cancer; however, whole total aberrations without any idea of cancer type; chromosomal radiosensitivity might enlighten the possibility of predicting cancer risk.en_US
dc.identifier.citationKolusayın Ozar, M. Ö., Orta, T., Dizdar, Y., Kaytan Sağlam, E., Sağlam, S., Turna, A., Okutan, M., Demirci, S., Ozar, E., Dastan, K., & Yükseloğlu, E. H. (2021). Is chromosomal radiosensitivity a predictive tool for cancer risks? Fresenius Environmental Bulletin, 30(4A), pp. 4486-4498.en_US
dc.identifier.endpage4498en_US
dc.identifier.issue4Aen_US
dc.identifier.startpage4486en_US
dc.identifier.urihttps://hdl.handle.net/20.500.13055/103
dc.identifier.volume30en_US
dc.identifier.wosWOS:000658172800061en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorDaştan, Kadir
dc.language.isoenen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiationen_US
dc.subjectRadiosensitivityen_US
dc.subjectCancer Risk Predictionen_US
dc.subjectChromosome Aberrationsen_US
dc.titleIs chromosomal radiosensitivity a predictive tool for cancer risks?en_US
dc.typeArticleen_US
dspace.entity.typePublication

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