Ultra-fast liquid chromatographic determination of atomoxetine, duloxetine, paroxetine, fluoxetine and sertraline in tap water, urine, and pharmaceutical formulations using 7,7,8,8-tetracyanoquinodimethane as a derivatization reagent

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dc.authorid0000-0002-5840-7386
dc.authorid0000-0003-3666-8187
dc.authorid0000-0001-8455-1173
dc.contributor.authorÖnal, Cem
dc.contributor.authorCeylan, Burhan
dc.contributor.authorÖnal, Armağan
dc.date.accessioned2026-06-11T16:37:59Z
dc.date.available2026-06-11T16:37:59Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı
dc.description.abstractThe widespread consumption of pharmaceuticals, including both human and veterinary drugs, has resulted in the accumulation of these substances in aquatic ecosystems, presenting significant ecological threats. Psychoactive drugs, particularly antidepressants, raise particular concern due to their direct effects on brain chemistry. The growing contamination of global water systems, especially in urban environments, underscores the increasing presence of these substances in nature. A novel analytical method using UFLC-UV was developed and validated for the quantification of Atomoxetine (ATM), Duloxetine (DLX), Paroxetine (PRX), Fluoxetine (FLX) and Sertraline (SRT) in tap water, urine, and pharmaceutical samples. This technique relies on creating a purple chromogen through a displacement reaction with TCNQ in acetonitrile, with heating at 80 °C for 20 minutes. The processed sample was then injected into a C18 column. Separation was performed using acetonitrile–water (85:15) as mobile phase at 1.0 mL/min flow rate. Detection was carried out at 567 nm. The method showed linearity in the range of 10–100 ng/mL for all compounds. The validated procedure was successfully implemented to identify these antidepressants in tap water, urine, and pharmaceutical formulations. Recovery values were found between 95.41 to 100.85%. The LOD values ranged from 1.02 to 1.98 ng/mL in all of the sample matrices.
dc.identifier.citationÖnal, C., Ceylan, B., & Önal, A. (2026). Ultra-fast liquid chromatographic determination of atomoxetine, duloxetine, paroxetine, fluoxetine and sertraline in tap water, urine, and pharmaceutical formulations using 7,7,8,8-tetracyanoquinodimethane as a derivatization reagent. Revue Roumaine de Chimie, (1-2), pp. 103-110. https://doi.org/10.33224/rrch.2026.71.1-2.11
dc.identifier.doi10.33224/rrch.2026.71.1-2.11
dc.identifier.endpage110
dc.identifier.issn0035-3930
dc.identifier.issue1-2
dc.identifier.scopus2-s2.0-105040152644
dc.identifier.scopusqualityQ4
dc.identifier.startpage103
dc.identifier.urihttps://doi.org/10.33224/rrch.2026.71.1-2.11
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1512
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖnal, Cem
dc.institutionauthorid0000-0002-5840-7386
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofRevue Roumaine de Chimie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleUltra-fast liquid chromatographic determination of atomoxetine, duloxetine, paroxetine, fluoxetine and sertraline in tap water, urine, and pharmaceutical formulations using 7,7,8,8-tetracyanoquinodimethane as a derivatization reagent
dc.typeArticle
dspace.entity.typePublication

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