Role of p53 in human cancers
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
IntechOpen
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
TP53 codes tumor protein 53-p53 that controls the cell cycle through binding DNA directly and induces reversible cell-cycle arrest. The protein activates DNA repair genes if mutated DNA will be repaired or activates apoptotosis if the damaged DNA cannot be fixed. Therefore, p53, so-called the “guardian of the genome,” promote cell survival by allowing for DNA repair. However, the tumor-suppressor function of p53 is either lost or gained through mutations in half of the human cancers. In this work, functional perturbation of the p53 mechanism is elaborated at the breast, bladder, liver, brain, lung cancers, and osteosarcoma. Mutation of wild-type p53 not only diminishes tumor suppressor activity but transforms it into an oncogenic structure. Further, malfunction of the TP53 leads accumulation of additional oncogenic mutations in the cell genome. Thus, disruption of TP53 dependent survival pathways promotes cancer progression. This oncogenic TP53 promotes cell survival, prevents cell death through apoptosis, and contributes to the proliferation and metastasis of tumor cells. The purpose of this chapter is to discuss the contribution of mutant p53 to distinct cancer types.
Açıklama
Anahtar Kelimeler
p53, TP53, Mutation, Loss-Of-Function, Breast Cancer, Bladder Cancer, Liver Cancer, Brain Cancer, Osteosarcoma
Kaynak
p53 - A Guardian of the Genome and Beyond
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Açıkalın Çoşkun, K., Tutar, M., Al, M., Gök Yurttaş, A., Abay, E. C., Yürekli, N., Yeman Kıyak, B., Uçar, K., Tutar, Y. (2022). Role of p53 in human cancers. M. Anwar (Ed.), p53 - A Guardian of the Genome and Beyond. https://doi.org/10.5772/intechopen.101961
