Role of p53 in human cancers

Basit Öğe Kaydı
dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.contributor.authorAçıkalın Çoşkun, Kübra
dc.contributor.authorTutar, Merve
dc.contributor.authorAl, Mervenur
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorAbay, Elif Cansu
dc.contributor.authorYürekli, Nazlıcan
dc.contributor.authorYeman Kıyak, Bercem
dc.contributor.authorUçar, Kezban
dc.contributor.authorTutar, Yusuf
dc.contributor.editorAnwar, Mumtaz
dc.date.accessioned2022-11-29T13:10:20Z
dc.date.available2022-11-29T13:10:20Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractTP53 codes tumor protein 53-p53 that controls the cell cycle through binding DNA directly and induces reversible cell-cycle arrest. The protein activates DNA repair genes if mutated DNA will be repaired or activates apoptotosis if the damaged DNA cannot be fixed. Therefore, p53, so-called the “guardian of the genome,” promote cell survival by allowing for DNA repair. However, the tumor-suppressor function of p53 is either lost or gained through mutations in half of the human cancers. In this work, functional perturbation of the p53 mechanism is elaborated at the breast, bladder, liver, brain, lung cancers, and osteosarcoma. Mutation of wild-type p53 not only diminishes tumor suppressor activity but transforms it into an oncogenic structure. Further, malfunction of the TP53 leads accumulation of additional oncogenic mutations in the cell genome. Thus, disruption of TP53 dependent survival pathways promotes cancer progression. This oncogenic TP53 promotes cell survival, prevents cell death through apoptosis, and contributes to the proliferation and metastasis of tumor cells. The purpose of this chapter is to discuss the contribution of mutant p53 to distinct cancer types.en_US
dc.identifier.citationAçıkalın Çoşkun, K., Tutar, M., Al, M., Gök Yurttaş, A., Abay, E. C., Yürekli, N., Yeman Kıyak, B., Uçar, K., Tutar, Y. (2022). Role of p53 in human cancers. M. Anwar (Ed.), p53 - A Guardian of the Genome and Beyond. https://doi.org/10.5772/intechopen.101961en_US
dc.identifier.doi10.5772/intechopen.101961en_US
dc.identifier.isbn9781839681462
dc.identifier.isbn9781839681455
dc.identifier.isbn9781839681479
dc.identifier.urihttps://doi.org/10.5772/intechopen.101961
dc.identifier.urihttps://hdl.handle.net/20.500.13055/324
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherIntechOpenen_US
dc.relation.ispartofp53 - A Guardian of the Genome and Beyonden_US
dc.relation.publicationcategoryKitap Bölümü - Ulusalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectp53en_US
dc.subjectTP53en_US
dc.subjectMutationen_US
dc.subjectLoss-Of-Functionen_US
dc.subjectBreast Canceren_US
dc.subjectBladder Canceren_US
dc.subjectLiver Canceren_US
dc.subjectBrain Canceren_US
dc.subjectOsteosarcomaen_US
dc.titleRole of p53 in human cancersen_US
dc.typeBook Chapteren_US
dspace.entity.typePublication

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