Antimicrobial and antibiofilm activities of paracetamol in combination with various antimicrobials

Basit Öğe Kaydı
dc.authorid0009-0009-9755-4483
dc.authorid0000-0003-0823-631X
dc.contributor.authorAltıner Kurt, Eda
dc.contributor.authorHacıoğlu, Mayram
dc.date.accessioned2026-01-08T14:06:26Z
dc.date.available2026-01-08T14:06:26Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground and Aims: In recent years, very few new antimicrobial agents have been approved and used for the treatment of infectious diseases. Paracetamol (acetaminophen) is one of the nonsteroidal anti inflammatory drugs with analgesic and antipyretic effects, which is frequently preferred and used safely in our country and in many other countries. In addition, because it is the most frequently prescribed drug after antibiotics and is often administered with antimicrobial therapy, understanding the interactions between these two drug classes is extremely important for drug repurposing. Methods: For this purpose, the effects of paracetamol alone or in combination with various antimicrobial agents and their activities on adhesion and biofilm formation were investigated against various standard bacteria and yeasts. Results: The minimum inhibitory concentration of paracetamol against standard strains was found 10,000 μg/mL, and the minimum bactericidal and fungicidal concentrations were found 10,000 - > 20,000 μg/mL. Cefepime and paracetamol combinations against Escherichia coli and Achromobacter xylosoxidans, and gentamicin and paracetamol combinations against Klebsiella pneumoniae and Acinetobacter baumannii showed synergistic effect. No antagonism was observed. According to the biofilm adhesion and formation inhibition assays, it was found that paracetamol was more effective against gram-negative bacteria than gram-positive bacteria and yeasts. Conclusions: In conclusion, this study proved that paracetamol, which is one of the most common analgesic and antipyretic agents in clinical use for many years, has antimicrobial and antibiofilm activity and can show synergistic effect in combination with various antibiotics.
dc.identifier.citationAltıner Kurt, E., & Hacıoğlu, M. (2025). Antimicrobial and antibiofilm activities of paracetamol in combination with various antimicrobials. İstanbul Journal of Pharmacy, 55(2), pp. 282-293. https://doi.org/10.26650/IstanbulJPharm.2025.1606484
dc.identifier.doi10.26650/IstanbulJPharm.2025.1606484
dc.identifier.endpage293
dc.identifier.issn2587-2087
dc.identifier.issue2
dc.identifier.startpage282
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2025.1606484
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1236
dc.identifier.volume55
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorAltıner Kurt, Eda
dc.institutionauthorid0009-0009-9755-4483
dc.language.isoen
dc.publisherIstanbul University Press
dc.relation.ispartofİstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParacetamol
dc.subjectAntimicrobial Activity
dc.subjectCombination
dc.subjectBiofilm
dc.subjectCheckerboard
dc.titleAntimicrobial and antibiofilm activities of paracetamol in combination with various antimicrobials
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
882.38 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Farmasötik Mikrobiyoloji Ana Bilim Dalı Koleksiyonu