Loteprednol loaded nanoformulations for corneal delivery: Ex-vivo permeation study, ocular safety assessment and stability studies

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÜner, Burcu
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorYıldırım, Ecem
dc.contributor.authorYaba, Aylin
dc.contributor.authorTaş, Çetin
dc.contributor.authorÜner, Melike
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2023-03-01T07:55:06Z
dc.date.available2023-03-01T07:55:06Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose Loteprednol etabonate (LE) is a topical corticosteroid that is used in inflammatory and allergic conditions of the eye. Nanoformulations including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsion (NE) of LE were prepared for increasing its ocular bioavailability and minimizing the risk of side effects. Methods Nanoformulations were prepared using hot emulsification and ultrasonication technique. The stabilities of the SLN, NLC, and NE were studied at different thermal conditions for 180 days. In this context, alterations in particle size (PS), zeta potential (ZP), viscosity, pH, %EE, and thermal behavior of the formulations were determined. Ex vivo corneal permeation study was performed, subsequently, the tape stripping approach was conducted for defining the LE amount that was blocked by the tear film layer. In addition, to determine the LE amount in epithelial tissue, a homogenization test was performed. Results the PS of the formulations was between 82.23 and 126.9 nm, and ZPs were between −20.8 mV and −24.6 mV. Furthermore, SLN, NLC, and NE formulations were found to be 2.05, 1.86, and 1.39 times higher LE retained in the cornea against the marketed product, respectively. Conclusion SLN, NLC, and NE might be alternative delivery systems by reducing the amount of LE for each dose and being used safely based on the results both of MTT and histopathological examinations as well.en_US
dc.identifier.citationÜner, B., Özdemir, S., Yıldırım, E., Yaba, A., Taş, Ç., Üner, M., & Özsoy, Y. (2023). Loteprednol loaded nanoformulations for corneal delivery: Ex-vivo permeation study, ocular safety assessment and stability studies. Journal of Drug Delivery Science and Technology, 81, pp. 1-10. https://doi.org/10.1016/j.jddst.2023.104252en_US
dc.identifier.doi10.1016/j.jddst.2023.104252en_US
dc.identifier.endpage10en_US
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85147923460en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.13055/402
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2023.104252
dc.identifier.volume81en_US
dc.identifier.wosWOS:000944367000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLoteprednol Etabonateen_US
dc.subjectNanoemulsionen_US
dc.subjectNanostructured Lipid Carriersen_US
dc.subjectOcular Deliveryen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectTopical Corticosteroidsen_US
dc.subjectCorneal Histopathologyen_US
dc.titleLoteprednol loaded nanoformulations for corneal delivery: Ex-vivo permeation study, ocular safety assessment and stability studiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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