A liquid chromatographic analysis of deferasirox in human breast milk with fluorimetric detection

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dc.contributor.authorÖnal, Cem
dc.contributor.authorTekkeli Kepekçi, Şerife Evrim
dc.contributor.authorSağıroğlu, Ali Asram
dc.date.accessioned2021-12-23T12:24:27Z
dc.date.available2021-12-23T12:24:27Z
dc.date.issued2020en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractTo determine deferasirox in human breast milk a novel, sensitive high-performance liquid chromatographic method with fluorescence detection has been developed. Precolumn derivatization process is applied to achieve fluorescent analyte using 4-bromomethyl-7-methoxy coumarin (BrMmC) as a reagent and dibenzo-18-crown-6-ether as catalyst. The method depends on reverse phase chromatography. C(18)column has been used with 150 x 4.6 mm, 5 mu m particle size and the mobile phase consisting of acetonitrile:phosphate buffer (20 mM, pH 3) (70:30,v/v) with a flow rate of 1.0 mL/min. Fluorescence detection at 390 nm is provided with an excitation at 320 nm The linear range is 0.01-1.0 mu g/mL. The mean recovery has been calculated as 100.7% with a relative standard deviation (RSD) value less than 2%. The developed method was successfully applied for the determination of deferasirox in human breast milk samples.en_US
dc.identifier.citationÖnal, C., Tekkeli, S. E. K., & Sağıroglu, A. A. (2020). A Liquid Chromatographic Analysis of Deferasirox in Human Breast Milk with Fluorimetric Detection. Chromatographia. 83(11), pp. 1329-1333. https://doi.org/10.1007/s10337-020-03953-5en_US
dc.identifier.doi10.1007/s10337-020-03953-5en_US
dc.identifier.endpage1333en_US
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85090498154en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1329en_US
dc.identifier.urihttps://doi.org/10.1007/s10337-020-03953-5
dc.identifier.urihttps://hdl.handle.net/20.500.13055/110
dc.identifier.volume83en_US
dc.identifier.wosWOS:000568232100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖnal, Cem
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChromatographiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDefarasiroxen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectFluorescence Detectionen_US
dc.subjectHuman Breast Milken_US
dc.titleA liquid chromatographic analysis of deferasirox in human breast milk with fluorimetric detectionen_US
dc.typeArticleen_US
dspace.entity.typePublication

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