Fat restriction at various developmental periods cause different modulations on the lingual fatty acid binding proteins

Basit Öğe Kaydı
dc.authorid0000-0002-3644-5066en_US
dc.authorwosidAAY-3447-2021en_US
dc.contributor.authorGünalan, Elif
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorGemici, Burcu
dc.date.accessioned2021-12-13T12:49:00Z
dc.date.available2021-12-13T12:49:00Z
dc.date.issued2021en_US
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractBackground: The origin of food preferences can be associated withearly food experience and lingual fatty taste receptors have a vitalrole in fat sensation. Objective: To determine the effect of fatrestriction during maternal and/or maturation periods on oro-sensoral perception of fats, fatty taste preference and expression ofCD36 and GPR120 in circumvallate papillae of male offspringSprague Dawley rats. Methods: In our study, rats were exposed tocontrol diet (C)(13% energy-from-fat) and low-fat diet (LFD)(3%energy-from-fat) during the gestation- lactation (21 days-21 day)and maturation (120 days) periods. Experimental groups were C/C(n=6), C/LFD (n=8), LFD/C (n=6) and LFD/LFD (n=8). Animalweight, energy and fat intake of the offsprings were followed duringthe study. The fat perception of the rats were measured bybehavioral tests. The plasma insulin and leptin levels weredetermined with ELISA. Blood glucose and triglyceride levels weremeasured by metabolic analyzer. The protein and mRNA expressionsof CD36 and GPR120 in the circumvallate papillae were determinedby western blotting, immunofluorescence, and RT-PCR. Results: Thisstudy has demonstrated that C/LFD group rats have significantlyincreased preference to 2% rapeseed oil solution than C/C group(pb0.05). Consistently, lingual CD36 and GPR120 expressions aresignificantly lower in C/LFD group (pb0.05). In addition, LFDadministration during maternal period in LFD/C and LFD/LFD groupscaused to significantly increased expression of lingual CD36 andGPR120 (pb0.05). Conclusion: This study has been contributed toidentify the developmental dysregulations of the oro-sensoralsignaling pathways and abnormal fatty taste perception.en_US
dc.identifier.citationGünalan, E., Yılmaz, B., & Gemici, B. (2021). Fat Restriction At Various Developmental Periods Cause Different Modulations On The Lingual Fatty Acid Binding Proteins. Metabolism, 116, pp. 58-58. https://doi.org/10.1016/j.metabol.2020.154610en_US
dc.identifier.doi10.1016/j.metabol.2020.154610en_US
dc.identifier.endpage58en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1016/j.metabol.2020.154610
dc.identifier.urihttps://hdl.handle.net/20.500.13055/82
dc.identifier.volume116en_US
dc.identifier.wosWOS:000614658000144en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGünalan, Elif
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMetabolismen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD36en_US
dc.subjectDevelopmental Programming Fat Restrictionen_US
dc.subjectGPR120en_US
dc.subjectMaternal Dieten_US
dc.titleFat restriction at various developmental periods cause different modulations on the lingual fatty acid binding proteinsen_US
dc.typeConference Objecten_US
dspace.entity.typePublication

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