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https://hdl.handle.net/20.500.13055/63

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Post-processing protocols in 3d printed dental restorations: A literature-based data analysis
(Dennis Barber Journals, 2025) Mert, Selen Elif; Özkan, Yiğit Alp; Olkun, Abdullah Yaşar; Dilaverler Yardım, Esra Ayşe
Objectives: This literature-based data analysis aims to evaluate the effects of post-processing protocols on the physical, mechanical, and surface properties of dental restorations produced using 3D printing technologies (SLA, DLP, and LCD systems). The objective is to highlight the variability in current approaches and thematically analyze the clinical implications of these differences. Materials-methods: A systematic search of the literature published between 2018 and 2025 was conducted using PubMed, Scopus, and Web of Science databases, in accordance with PRISMA guidelines. Inclusion criteria were: (1) studies involving 3D printed resins, (2) evaluation of at least one post-processing variable (e.g., curing, cleaning, or support removal), and (3) focus on definitive or interim prosthodontic restorations. Studies involving orthodontic models, aligners, or CAD/CAM-milled restorations were excluded. The included studies were categorized into three groups: curing protocols, cleaning procedures, and support structure removal. Due to methodological heterogeneity, no meta-analysis was performed; instead, findings were interpreted through a descriptive, literature-based data analysis approach. RESULTS: A total of approximately 320 unique studies were identified through prior systematic and narrative reviews. After applying predefined inclusion criteria, 12 studies were selected for in-depth evaluation in this literature review. Although some included studies were systematic reviews and meta-analyses, this study did not perform an independent meta-analysis. Variations in curing time, light intensity, and atmospheric conditions were found to affect degree of conversion, microhardness, and flexural strength. Cleaning protocols involving different solvents and application techniques influenced surface roughness and dimensional accuracy. The support removal process impacted marginal adaptation, surface integrity, and gloss retention. Despite methodological differences, the overall evidence indicates that post-processing parameters significantly influence clinical performance outcomes. Conclusion: This analysis demonstrates that post processing protocols significantly affect material quality and clinical applicability. The findings underscore the need for manufacturer-independent, standardized protocols to ensure predictable outcomes in 3D printed dental restorations.
Weibull characteristics and modulus calculation in adhesion studies: A methodological investigation
(Dennis Barber Journals, 2025) Berisha, Florentin; Şener, Alpaslan; Cankja, Angelo; Uzun Pekintürk, Berre; Freitas Brum Souza, Luiza; Özcan, Mutlu
Objective: This study aimed to determine the minimum number of specimens required to obtain statistically reliable conclusions in adhesion studies using the Weibull statistic and to estimate the probability of failure under defined conditions. Materials-methods: Specimens (N=160) were prepared from resin composite (RC: Brilliant, Coltene), lithium disilicate (LD: IPS e.max Press, Ivoclar), zirconia (YZ: Z-CAD, Metoxid AG), and titanium (TI: Ti CP Grade 4, Permascand). RC, YZ, and TI were air-abraded (50 µm Al2 O2 , 2.5 bar, 10 s), and LD was etched with 5% hydrofluoric acid (20 s). Resin cement cylinders (Ø=3×4 mm) were bonded using one of the following: Variolink Esthetic DC (Ivoclar), Panavia V5 (Kuraray Noritake), Panavia 21 (Kuraray Noritake), or Multilink Automix (Ivoclar). The combinations tested were as follows: RC-Variolink Esthetic DC/Panavia V5; LD-Variolink Esthetic DC/Panavia V5; YZ-Panavia 21/Multilink Automix; TI Panavia 21/Multilink Automix. Half of the specimens were stored at 37 °C for 24 h; the other half underwent thermocycling (x6000, 5-55 °C). Shear bond strength was tested (1 mm/min), and failure modes were assessed under digital microscopy. Weibull analysis evaluated bond reliability for 10, 20, 30 and 40 specimens in each group. Maximum likelihood estimation and 95% confidence intervals determined differences. Results: For RC, Variolink Esthetic DC showed higher characteristic strength (η) at n=10 and 20 vs. n=30 and 40. Panavia V5 showed a significant decrease from n=10 to 40 only in the non-aged condition. In LD, both cements showed decreasing η with increasing n. In YZ and TI, both Panavia 21 and Multilink Automix showed reduced characteristic strength with increasing n. Failures were mainly cohesive in LD but adhesive with the other materials. Conclusions: Increasing sample size reduced characteristic strength (η) across all materials, indicating that small sample sizes overestimate adhesive performance. Larger samples yield more reliable estimates. The Weibull modulus (β) remained stable or increased slightly after aging, especially for zirconia.
Prosthetic rehabilitation of a large maxillary defect due to nasopharyngeal tumor resection: A case report
(Dennis Barber Journals, 2025) Topuz, Buğra Tuğ; Kasıl, Ece; Ayvalıoğlu Şamiloğlu, Demet Çağıl
Introduction: Nasopharyngeal tumors are malignant neoplasms located in the epithelial lining of the nasopharynx, and they often require aggressive treatment modalities including surgery, radiotherapy, and/or chemotherapy. Surgical resection of these tumors, especially when involving adjacent maxillary and palatal structures, frequently results in large maxillofacial defects. This case report presents the comprehensive prosthetic rehabilitation of a patient with a large acquired maxillary defect following surgical resection of a nasopharyngeal tumor. Case Description: A 49 years old male patient with a large maxillary defect resulting from extensive surgical nasopharyngeal tumor resection applied to the clinic of Department of Prosthodontics. Following surgery, the patient had received postoperative radiotherapy and chemotheraphy. Prior to definitive prosthetic rehabilitation, endodontic and periodontal treatments of the remaining teeth were completed. Support was taken from the remaining teeth (16-15, 12-11-21- 22) to fabricate a precision attachment-retained obturator that provided partial separation between the oral and nasal cavities. A quadrilateral design was performed. For the mandibular partial edentulism, a precision attachment-retained, metal framework removable partial denture was designed. Results: The patient’s issues with speech and nutrition deficiency were resolved with the obturator prosthesis and the esthetic demands were fullfilled. Conclusion: Within the scope of this case, the use of an obturator provided functional and esthetic rehabilitation of a patient with a large maxillary defect following oncologic surgery.
Prosthetic approach to tooth structure damage associated with dietary habits and bruxism: A case report
(Dennis Barber Journals, 2025) Özkan Dayıoğlu, Selin; Ayvalıoğlu Şamiloğlu, Demet Çağıl; Rastgar Safari, Mahya
Introduction: Tooth structure loss resulting from parafunctional habits such as bruxism, compounded by erosive dietary factors, presents a multifactorial challenge in restorative dentistry. Patients often exhibit a combination of advanced anterior wear, dentin hypersensitivity, and non carious cervical lesions. Successful rehabilitation requires a minimally invasive, esthetically driven, and functionally stable prosthetic approach. This case presents a comprehensive adhesive and occlusal strategy for managing tooth wear caused by bothbruxism and dietary habits. Case Description: A 54-year-old female patient presented with severe anterior tooth wear, dentin hypersensitivity, and non carious cervical lesions attributed to parafunctional habits, particularly bruxism. The maxillary central incisors exhibited significant structural compromise and esthetic concerns. To fulfill the functional and esthetic needs of the patient, lithium disilicate crowns were placed on the maxillary central incisors. Additionally, seven maxillary anterior teeth were restored using minimally invasive lithium disilicate laminate veneers. A monolithic zirconia crown was placed on the maxillary first molar to reinforce posterior occlusal support. Tooth preparations followed adhesive principles, and the occlusion was carefully evaluated and adjusted. A protective occlusal splint was delivered post-treatment to eliminate future damage. Discussion: This case emphasizes the importance of early diagnosis and a comprehensive, adhesive-based prosthodontic treatment plan in managing bruxism induced tooth wear. Lithium disilicate ceramics allowed for both conservative tooth preparation and high esthetic outcomes. The use of a monolithic zirconia crown in the posterior ensured durability. The integration of occlusal assessment and an occlusal splint served as critical components for maintaining long-term stability. Conclusion: Through a customized, adhesive prosthodontic strategy, it was possible to restore esthetics, relieve sensitivity, and prevent further damage in a patient affected by bruxism.
Photogrammetry-assisted digital workflow for full-arch monolithic zirconia restorations: A clinical report
(Dennis Barber Journals, 2025) Güler, Edanur; Sabancı, Nibal; Dilaverler Yardım, Esra Ayşe
Introduction: Achieving cross-arch accuracy and passive fit remains a major challenge in conventional impression techniques for full-arch implant restorations. In contrast, photogrammetry-assisted digital workflows offer enhanced precision, efficiency, and predictability. This clinical report describes the rehabilitation of a 56-year-old fully edentulous female patient using a fully digital protocol and monolithic zirconia prostheses for both jaws. Case Description: Twelve endosseous implants (Ø3.7 mm, length 10–12 mm; ETK, France) were placed in anterior and posterior regions of the maxilla and mandible. After successful osseointegration, multi-unit abutments were connected. Final impressions were obtained using a hybrid protocol that combined photogrammetry (Imetric-Icam, Switzerland) with intraoral scanning (iTero Lumina, USA). With reference bars in place, interocclusal records and vertical dimension were registered using C-type vinyl siloxane ether (Zetaplus, Zhermack, Italy). Facial photographs and marker data were recorded in natural head position and transferred to the laboratory. Digital alignment and virtual articulation (Artex, Germany) were performed. A CAD-CAM resin mock-up (Armaresin, Turkey) was fabricated and evaluated intraorally for esthetics and occlusion. Final restorations were designed as full-arch, screw-retained prostheses using monolithic zirconia (Ceramill Zolid FX, Amann Girrbach, Austria) and torqued to 15 Ncm. Discussion: The photogrammetry-based workflow demonstrated superior cross-arch accuracy and passive fit compared to conventional techniques. The try-in allowed for verification of occlusal harmony, vertical dimension, and esthetics in a single appointment. Follow-up at 1-, 3-, 6-month, and 1-year intervals revealed no peri-implant complications. The patient reported high satisfaction in function and esthetics. This case highlights the clinical advantages of photogrammetry and monolithic zirconia in streamlining full-arch implant rehabilitation.
Mandibular overdenture supported by two canines: A two-year clinical follow-up case report
(Dennis Barber Journals, 2025) Eyidemir, Bahar; Güler, Edanur; Papatya, Zeynep; Dilaverler Yardım, Esra Ayşe
Introduction: Mandibular complete dentures often present insufficient retention and stability due to anatomical limitations in edentulous patients. Although implant therapy is commonly used to address these issues, it may not be feasible in patients with systemic conditions that contraindicate surgical interventions. In such cases, preserving and utilizing remaining natural teeth as abutments can enhance prosthetic success while minimizing invasiveness and improving patient comfort. Tooth-supported overdentures are a valuable alternative, particularly when strategic teeth such as canines are available. Case Description: A 60-year-old male patient with a history of diabetes mellitus presented with complaints of instability in his mandibular complete denture. The patient exhibited a fully edentulous maxilla and retained only two mandibular canines. Implant therapy was contraindicated due to his systemic condition. As an alternative, a tooth supported mandibular overdenture was planned. Clinical and radiographic evaluations confirmed that both canines were periodontally and structurally suitable for overdenture support. Endodontic treatment was performed, and the clinical crowns were reduced to allow sufficient space for prosthetic components. Cast copings with ball attachments were fabricated and cemented. A mandibular overdenture incorporating matching female housings was constructed and delivered. A conventional complete denture was also fabricated for the maxilla. The patient was recalled every six months for clinical evaluation and maintenance. Over a two-year follow-up period, no complications such as attachment loosening, mucosal irritation, or abutment failure were observed. The patient reported high satisfaction in terms of masticatory function, prosthesis stability. Discussion: This case demonstrates that, in patients for whom implant therapy is contraindicated, mandibular overdentures supported by two natural canines with ball attachments can offer a stable, functional, and long-term treatment solution. Tooth-supported overdentures provide biomechanical advantages and improve patient satisfaction through a minimally invasive approach. The strategic use of retained natural teeth, particularly canines, remains a clinically effective alternative for managing mandibular edentulism.
Functional and esthetic outcomes of full-mouth rehabilitation following vertical dimension reestablishment using posterior composite build-ups: A case report
(Dennis Barber Journals, 2025) Papatya, Zeynep; Güler, Edanur; Karabulut, Dicle; Özdal, Umut
Introduction: Loss of vertical dimension of occlusion (VDO) is a clinical condition that can significantly impact both function and esthetics. It may lead to impaired mastication, temporomandibular joint (TMJ) discomfort, facial disharmony, and reduced quality of life. Restoring VDO requires a systematic approach involving proper evaluation, neuromuscular adaptation, and establishment of a stable occlusal and TMJ relationship. This case report presents the functional and esthetic outcomes of full-mouth rehabilitation following VDO reestablishment using posterior composite build-ups and a gradual increase in occlusal height to promote TMJ stabilization. Case Description: A patient with reduced VDO was treated with posterior composite resin build-ups. The vertical dimension was increased by 1 mm per week over five weeks, allowing neuromuscular adaptation and TMJ repositioning. After successful adaptation, definitive restorations were completed. Pressable ceramic (e.max) laminate veneers were placed from first premolar to first premolar (5–5) in both arches. Zirconia crowns were used on the first and second molars (6 and 7). Throughout the procedure, esthetic, functional, and occlusal parameters were carefully monitored to ensure optimal outcomes. The patient adapted well to the new VDO, showing marked improvement in facial esthetics and occlusal function. High patient satisfaction was reported at the conclusion of treatment. Discussion: This case highlights the effectiveness of a controlled, stepwise approach to VDO restoration. Using composite build-ups allowed reversible testing of neuromuscular tolerance before final restorations. The combination of e.max veneers and zirconia crowns restored function and esthetics while preserving TMJ stability. No complications were observed during the one-month follow up, supporting the short-term success of the approach. Long term monitoring is essential to confirm the durability of results.
Endocrown-based restoration of a structurally compromised tooth using additive manufacturing in a fully digital workflow: A case report
(Dennis Barber Journals, 2025) Keskin, Muhammed Furkan; Altaş, Zeynep Tuğçe; Dilaverler Yardım, Esra Ayşe
Introduction: The rapid advancement of digital technologies in dentistry has facilitated the effective integration of CAD/CAM systems into restorative treatment protocols. These systems enable both subtractive and additive manufacturing methods to be incorporated into clinical workflows. Endocrowns, preferred for restoring endodontically treated teeth with compromised structural integrity, offer significant advantages in terms of precision and time efficiency when digitally planned and fabricated. Case Description: A 33-year-old male patient presented to the clinic with complaints of acute dental pain. Clinical and radiographic evaluations revealed deep dentinal caries and extensive coronal substance loss in the affected tooth, for which endodontic treatment was indicated. Following root canal therapy, an endocrown restoration was selected to preserve the remaining tooth structure and restore functional integrity. The treatment was carried out entirely using a digital workflow. An intraoral scanner (TRIOS® 3 Color, 3Shape, Denmark) was used to capture the digital impression. The restoration was designed using CAD software (Exocad, Germany) and subsequently fabricated using additive manufacturing technology with a 3D printer (Asiga MAX, Australia) and high-precision dental resin. The restoration was cemented using adhesive techniques in a clinical setting. Discussion: Endocrowns fabricated through a fully digital workflow demonstrate superior accuracy, workflow standardization, and time efficiency compared to conventional methods. Additive manufacturing enables the precise production of complex morphologies, eliminates the need for physical models, reduces material waste, and enhances cost-effectiveness. These restorations exhibit high clinical compatibility and improve patient comfort while reducing operator dependency during production. However, limitations such as high system acquisition costs, the need for technical proficiency, and limited long-term clinical data must be considered for widespread adoption.
Digitally planned prosthetic rehabilitation of a patient with inadequate interocclusal space
(Dennis Barber Journals, 2025) Olkun, Abdullah Yaşar; Özkan, Yiğit Alp; Albayrak, Berkman
Introductıon: In cases where missing teeth are not replaced for a long time, the opposing teeth may come into supra-occlusion and this can make the prosthetic rehabilitation to be applied quite difficult. Digital wax-up enables planning a predictable treatment for patients and to perform rehabilitation in the appropriate vertical dimension. Case Description: A 46-year-old male patient with moderate periodontal health who had lost his centric stop due to posterior tooth loss applied to our clinic for prosthetic treatment. During the clinical examination, it was noticed that the antagonist teeth had erupted over time and deep-bite had occurred because the missing teeth was not replaced. Both digital and conventional impressions were made and the diagnostic casts with face-bow registration were transferred to a semi-adjustable articulator. Then, it was planned to increase the vertical dimension by 3 mm and to provide sufficient interocclusal distance by extracting the right maxillary second molar and the left mandibular first and second molars. Accordingly, digital wax-up was prepared on the anterior teeth and a 3D-printed wax-up with denture bases was prepared for the posterior teeth. After the aesthetic and functional analyses were performed, anterior teeth were prepared in the guidance of mock-up and silicone indexes to ensure obtaining sufficient clearance. The maxillary arch was rehabilitated with 3 separate metal-ceramic fixed partial denture and the mandibular jaw was rehabilitated with a single 9-unit fixed partial denture. By increasing the vertical dimension and obtaining sufficient interocclusal distance, posterior edentulous areas were also rehabilitated with removable partial dentures. Discussion: In cases where prosthetic planning and predict both aesthetics and function after treatment are difficult, more precise treatment plans can be offered to patients by performing digital design prior to any intervention. In this case, a predictable rehabilitation was achieved by increasing the vertical dimension thanks to digital wax-up.
The relationship between sleep quality and dietary habits in apprentice jockeys
(IBPEFEX - Instituto Brasileiro de Pesquisa e Ensino em Fisiologia do Exercício, 2026) Ayar, Muttalip; Mor, Ömer; Şahin Anılgan, İrem Nur; Atar, Aslıhan; Özbey, Fatih
Introduction: Adequate sleep is vital for young athletes, and diet may play a role in sleep quality. This is especially relevant for apprentice jockeys who face unique physical and nutritional demands. Objective: To examine the relationship between dietary habits and sleep quality in apprentice jockeys at the Turkish Jockey Club Ekrem Kurt Apprentice Training Center. Materials and Methods: Twenty-four male apprentice jockeys (15-18 years) completed 7-day food and fluid intake records. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI). Anthropometric measurements were collected. Associations between nutrient intake and PSQI components were analyzed with Spearman’s correlation. Results: The mean PSQI score was 4.96 ± 2.84, and 41.7% of participants were poor sleepers. Total energy and macronutrient intake were not associated with overall PSQI. However, certain nutrients showed meaningful relationships with specific sleep components. Higher zinc intake, especially in the evening, was linked to better subjective sleep quality, while higher evening fat intake was associated with poorer sleep. Protein and fat intake showed negative correlations with subjective sleep quality. Evening carbohydrate proportion was related to fewer sleep disturbances. Conclusions: Although overall dietary intake did not affect global sleep quality, selected nutrients and meal timing were associated with specific aspects of sleep.
From awareness to action: Do the food safety attitudes affect sustainable food consumption behaviors in university students?
(Frontiers Media S. A., 2026) Pınarlı Falakacılar, Çağla; Bilginer Diler, Gamzegül; Terzi, Merve
Background: Ensuring food safety and promoting sustainable food consump tion are increasingly important public health priorities, especially among young adults who are forming long-term dietary habits. This study explored how univer sity students’ food safety attitudes relate to their sustainable food consumption behaviors. Methods: This cross-sectional study was conducted with 360 university students between May and September 2024. Validated scales were used to measure food safety attitudes (FSAS) and sustainable food consumption behaviors (SFCBS). Additional data collected included gender and body mass index (BMI). Statistical analyses evaluated differences between groups and correlations among key variables. Results: The findings showed that 83.3% of participants had adequate food safety attitudes. Female students scored significantly higher than males on both the food safety attitude and SFCBS scales, including subdimensions such as caring, assimilating, and shopping/cooking habits (p < 0.05). A moderate positive corre lation was identified between FSAS and SFCBS, particularly for general nutritional behaviors (r = 0.446, p < 0.05). Additionally, positive correlations were found between SFCBS and FSAS subdimensions. Conclusion: Overall, the results indicate that female students exhibit stronger food safety attitudes and sustainable food consumption behaviors, and that fos tering awareness of these practices during university years may contribute to healthier, more environmentally responsible lifestyles in line with global sustain ability goals.
Protetik diş hekimliğinde fotopolimer dental reçineler
(Gece Kitaplığı, 2025) Dilaverler Yardım, Esra Ayşe; Mert, Selen Elif
Protetik diş hekimliğinde kullanılan üretim yöntemleri, son yıllarda dijital teknolojilerin gelişimine paralel olarak önemli bir dönüşüm süre cinden geçmektedir. Geleneksel döküm, presleme ve frezeleme temelli üretim yöntemlerinin yerini, bilgisayar destekli tasarım ve üretim sistem leri (Computer-Aided Design/Computer-Aided Manufacturing – CAD/ CAM) ile birlikte eklemeli üretim teknolojileri (Additive Manufacturing – AM) almaya başlamıştır. Bu teknolojiler, üretim doğruluğunu ve işlem hızını artırarak materyal kullanımında verimlilik sağlamış, aynı zaman da kişiye özgü protetik restorasyonların üretilmesini mümkün kılmıştır.
Video-assisted learning on youtube in dentistry education: The impact of overdenture videos on dentistry students
(Dennis Barber Journals, 2025) Olkun, Abdullah Yaşar; Özkan, Yiğit Alp; Dilaverler Yardım, Esra Ayşe
OBJECTIVES: This study aimed to evaluate the effectiveness of video-assisted learning on the knowledge and perceptions of dental students regarding implant-supported overdentures, which represent a challenging but essential aspect of prosthodontic treatment. The increasing use of digital platforms for educational purposes motivated this research. MATERIALS-METHODS: A prospective pretest–posttest intervention study was conducted involving 4th- and 5th-year dental students at Istanbul Health and Technology University. Participants initially completed a 15-item multiple-choice test designed to assess their baseline theoretical knowledge of implant supported overdenture procedures. Students watched the selected educational video demonstrating key clinical steps, including implant positioning, abutment selection, impression-taking techniques, and prosthesis fitting. After the video session, students completed the same knowledge test to evaluate knowledge gain, as well as a 10-item Likert-scale survey to assess their perceptions about the video’s clarity, educational value, engagement, and motivational impact. Data were statistically analyzed using paired t-tests for knowledge score comparisons and descriptive statistics for survey results.Students complete the survey via Google Forms. RESULTS: Analysis revealed a statistically significant increase in post-intervention test scores, indicating an improvement in students’ understanding of overdenture concepts and clinical procedures. Survey responses reflected positive student attitudes toward video-assisted learning, highlighting increased clarity, engagement, and confidence in managing implant-supported overdentures. Most students expressed a preference for integrating similar video modules into their formal prosthodontic education. CONCLUSION: Video-assisted learning through widely accessible platforms such as YouTube serves as an effective supplementary educational tool in dental training. It enhances both theoretical knowledge and practical confidence in complex prosthodontic procedures like implant-supported overdentures. Incorporating such multimedia resources into dental curricula is strongly recommended to enrich student learning experiences and outcomes.
In vitro evaluation of methyl methacrylate (MMA) release from different temporary denture base materials
(Dennis Barber Journals, 2025) Dilaverler Yardım, Esra Ayşe; Özer, Safa; Atasoyu Akgün, Begüm; Çakan, Umut
INTRODUCTION: Residual methyl methacrylate (MMA) released from temporary denture base materials is of clinical concern due to its potential biological effects. Recently, light polymerized and 3D-printed denture base resins have emerged as alternatives to conventional cold-polymerized acrylics. This study aimed to compare the in vitro MMA release levels of three clinically relevant temporary denture base materials. MATERIALS AND METHODS: Three materials were tested: cold-polymerized acrylic resin, light-polymerized baseplate resin, and 3D-printed denture base resin. Ten samples were prepared for each group (n=10), standardized to 0.05 g per specimen. Samples were immersed in 2 mL and 5 mL of artificial saliva and incubated at 37°C. MMA release was quantified using high-performance liquid chromatography (HPLC) at 15 minutes, 30 minutes, 1 hour, and 24 hours. Data distribution was analyzed with the Shapiro-Wilk test; the effects of time, material, and saliva volume were assessed using two-way ANOVA and Tukey post-hoc tests (p<0.05). RESULTS: No MMA release was detected before 24 hours in the 3D-printed and light-polymerized groups. The cold polymerized acrylic group showed progressive MMA release starting from 15 minutes, with a significant increase over time (p<0.001). At 24 hours, it exhibited the highest MMA levels among all groups. A significant difference between 2 mL and 5 mL saliva volumes was observed only in the cold-cure group. The 3D-printed resin showed the most stable performance across all time points. CONCLUSION: Temporary denture base materials should be selected with consideration of residual monomer release. The results support the biocompatibility of 3D-printed resins for short-term clinical applications, especially when early MMA release and toxicity are of concern.
Epigenetic mechanisms of caffeine on athletes
(Nutrigenetik Epigenetik Derneği, 2025) Divanoğlu, Ömer; Ercan Karakaya, Zeynep; Mutlu, Hayrettin
Introduction: Caffeine is one of the most widely used ergogenic aids in sports, known to enhance endurance, strength, and reaction speed. While its effects have traditionally been attributed to adenosine receptor antagonism and increased calcium release, recent studies suggest that caffeine may also influence epigenetic mechanisms that regulate gene activity without altering the genetic sequence, primarily through DNA and histone modifications. Mechanismssuch as DNA methylation (the addition of methyl groups that suppress gene transcription) and histone acetylation (relaxing chromatin structure to activate genes) play a crucial role in exercise-induced skeletal muscle adaptation.
Epigenetic effects of caffeine
(Nutrigenetik Epigenetik Derneği, 2025) Ercan Karakaya, Zeynep; Mutlu, Hayrettin
Purpose: Caffeine is one of the most widely consumed bioactive compounds worldwide, naturally found in coffee and cocoa beans, tea leaves, guarana berries, and kola nuts. In recent years, the effects of caffeine consumption on chronic diseases, neurological disorders, and pregnancy outcomes have attracted attention, particularly in relation to epigenetic mechanisms. The aim of this study is to evaluate the epigenetic effects of caffeine and their potential health implications.
Epigenetic effects of caffeine on muscle in athletes
(Nutrigenetik Epigenetik Derneği, 2025) Divanoğlu, Ömer; Ercan Karakaya, Zeynep; Mutlu, Hayrettin
Objective: Caffeine is one of the most common ergogenic aids known to increase endurance, strength, and reaction time in athletes. Although its effects are generally thought to be mediated by adenosine receptor antagonism and its stimulatory role in calcium release, recent studies have revealed that caffeine may also influence epigenetic regulatory mechanisms. Epigenetic mechanisms are biochemical processes that alter gene activity without any changes to the DNA sequence, and these processes include DNA methylation, histone acetylation, and microRNA regulation.
Exploring nutritional supplement use by Turkish handball players: A pilot study
(Instituto Politécnico de Setúbal, 2025) Mor, Ömer; Bayraktar, Bülent; Sanchez-Oliver, Antonio Jesus; Günalan, Elif
Handball is popular with high physical, physiological, and psychological demands. In addition to high-intensity movements, handball players must have performance components such as strength, agility, and speed and a suitable aerobic form to cope with high-intensity efforts. An optimal nutrition strategy helps maintain physical and cognitive performance, supports injury prevention, return to play, training adaptations, accelerates, and optimizes recovery processes. It has been stated in the literature that handball players tend to use nutritional supplements (NS) to facilitate the achievement of their nutritional goals. Therefore, studying how handball athletes use NS can offer an important understanding of the factors influencing their success. This study investigates supplement use among Turkish handball players and assessing the factors that shape their supplementation practices.
Sports drinks may affect salivary parameters in adolescent footballers
(Instituto Politécnico de Setúbal, 2025) Bakdım, Kürşat; Yılmaz, Şeyda; Kement, Sevgi; Küçük, Fatih Berkay; Sücüllülü, Beyza Nur; Yalvaç, Seda; Vural, Yasemin; Saygılı, Seda; Özüpek, Gökçen; Özgün, Mete; Keskin, Melih; Özen, Buğra; Günalan, Elif
Many adolescent athletes turn to sports supplements (SS) to improve their performance. Still, the growing use of these products raises questions about how they might affect oral health in the long run. While most studies focus on adult athletes and link sports drink consumption to dental issues like erosion and decay, it is worth asking whether these problems could begin much earlier, during the teenage years. This study explored how supplement use may influence salivary characteristics and early signs of oral health changes in adolescent football players.
Safe or dangerous? Evaluating group a sports supplements in the context of the epithelial barrier hypothesis
(Instituto Politécnico de Setúbal, 2025) Sadık, Merve; Aladağ, Esra; Bayraktar, Bülent; Sanchez-Oliver, Antonio Jesus; Günalan, Elif
The epithelial barrier hypothesis suggests that the integrity of epithelial barriers in the skin, respiratory tract, and intestinal mucosa contributes to various chronic diseases. Long-term and high-intensity training, dehydration, malnutrition, etc., can cause epithelial barrier sensitivity in elite athletes. Elite athletes commonly consume sports supplements (SS) to enhance performance, support physical appearance, and prevent nutrient deficiencies. Scientific evidence indicates that SS can also affect the integrity of epithelial barriers. This study aims to discuss the potential effects of SS classified as Group A by the Australian Sports Institute (AIS) on epithelial barrier integrity.

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