Delivery of curcumin within emulsome nanoparticles enhances the anti‑cancer activity in androgen‑dependent prostate cancer cell

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dc.authorid0000-0003-4789-9095en_US
dc.authorscopusid57212405586en_US
dc.contributor.authorBolat, Zeynep Büşra
dc.contributor.authorİşlek, Zeynep
dc.contributor.authorŞahin, Fikrettin
dc.contributor.authorÜçışık, Mehmet Hikmet
dc.date.accessioned2023-01-08T13:33:57Z
dc.date.available2023-01-08T13:33:57Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractBackground Curcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various cancer types including prostate cancer. However, low water solubility and bioavailability of the compound are major challenges against its medical use. The objective of this study is to evaluate the therapeutic potential of curcumin-loaded emulsome nanoparticular system, i.e. CurcuEmulsomes, for the treatment of androgen dependent LNCaP prostate cancer cell line. Methods and results The antiproliferative efect of both free curcumin and CurcuEmulsome were investigated comparatively on LNCaP and PNT1A cells. Cell viability data indicates that the inhibition in proliferation of LNCaP cells becomes more efective when curcumin is provided with its emulsome formulation rather than its free form. Corresponding to a therapeutic index of 2.25, Half maximal inhibitory (IC50) and cytotoxic (CC50) concentrations of CurcuEmulsomes for LNCaP and PNT1A cells were estimated as 17.1 µM and 38.6 µM, respectively. The fuorescence signal of autofuorescence curcumin was preserved within the CurcuEmulsomes at 72 h after the treatment. Thus, CurcuEmulsomes prolonged biological activity of curcumin. Induced apoptotic cell death and stimulated cell cycle arrest at G2/M phase were attributed to antiproliferative activity of CurcuEmulsomes. Treatment of LNCaP cells with CurcuEmulsomes increased expression of caspase-3 signifcantly by 11.76-fold, whereas decreased cyclin D1, Bcl-2 and AR expression levels signifcantly by of 0.18, 0.06 and 0.46-fold, respectively. Conclusions Presented safety and anticancer activity of CurcuEmulsomes on LNCaP cell line highlights the potential of CurcuEmulsomes to beneft intrinsic anticancer activities of curcumin in androgen dependent prostate cancer therapyen_US
dc.description.sponsorshipTUBITAK -- 115C022en_US
dc.identifier.citationBolat, Z. B., İşlek, Z., Şahin, F. & Üçışık, M. H. (2023). Delivery of curcumin within emulsome nanoparticles enhances the anti‑cancer activity in androgen‑dependent prostate cancer cell. Molecular Biology Reports, 50(3), pp. 2531-2543. https://doi.org/10.1007/s11033-022-08208-0en_US
dc.identifier.doi10.1007/s11033-022-08208-0en_US
dc.identifier.endpage2543en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3en_US
dc.identifier.pmidPMID: 36607480en_US
dc.identifier.scopus2-s2.0-85145867298en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2531en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-022-08208-0
dc.identifier.urihttps://hdl.handle.net/20.500.13055/366
dc.identifier.volume50en_US
dc.identifier.wosWOS:000912377500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorİşlek, Zeynep
dc.language.isoenen_US
dc.publisherSpringerLinken_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAndrogen Dependent Prostate Canceren_US
dc.subjectCurcuminen_US
dc.subjectEmulsomeen_US
dc.subjectAnti-Canceren_US
dc.subjectPhytochemicalen_US
dc.titleDelivery of curcumin within emulsome nanoparticles enhances the anti‑cancer activity in androgen‑dependent prostate cancer cellen_US
dc.typeArticleen_US
dspace.entity.typePublication

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