Evaluation of the diagnostic performance of a SARS-CoV-2 and Influenza A/B combo rapid antigen test in respiratory samples

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dc.authorid0000-0002-7855-7779en_US
dc.authorscopusid57643484200en_US
dc.contributor.authorDinç, Harika Öykü
dc.contributor.authorKarabulut, Nuran
dc.contributor.authorAlaçam, Sema
dc.contributor.authorKırkoyun Uysal, Hayriye
dc.contributor.authorDaşdemir, Ferhat Osman
dc.contributor.authorÖnel, Mustafa
dc.contributor.authorTuyji Tok, Yeşim
dc.contributor.authorSirekbasan, Serhat
dc.contributor.authorAgaçfidan, Ali
dc.contributor.authorGareayaghi, Nesrin
dc.contributor.authorÇakan, Hüseyin
dc.contributor.authorEryiğit, Önder Yüksel
dc.contributor.authorKocazeybek, Bekir
dc.date.accessioned2023-03-08T06:21:31Z
dc.date.available2023-03-08T06:21:31Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programıen_US
dc.description.abstractThis study aimed to evaluate the performance characteristics of a rapid antigen test developed to detect SARS-CoV-2 (COVID-19), influenza A virus (IAV), and influenza B virus (IBV) (flu) compared with those of the real-time reverse transcription-polymerase chain reaction (rRT-PCR) method. One hundred SARS-CoV-2, one hundred IAV, and twenty-four IBV patients whose diagnoses were confirmed by clinical and laboratory methods were included in the patient group. Seventy-six patients, who were negative for all respiratory tract viruses, were included as the control group. The Panbio™ COVID-19/Flu A&B Rapid Panel test kit was used in the assays. The sensitivity values of the kit were 97.5%, 97.9%, and 33.33% for SARS-CoV-2, IAV, and IBV, respectively, in samples with a viral load below 20 Ct values. The sensitivity values of the kit were 16.7%, 36.5%, and 11.11% for SARS-CoV-2, IAV, and IBV, respectively, in samples with a viral load above 20 Ct. The kit’s specificity was 100%. In conclusion, this kit demonstrated high sensitivity to SARS-CoV-2 and IAV for viral loads below 20 Ct values, but the sensitivity values were not compatible with PCR positivity for lower viral loads over 20 Ct values. Rapid antigen tests may be preferred as a routine screening tool in communal environments, especially in symptomatic individuals, when diagnosing SARS-CoV-2, IAV, and IBV with high caution.en_US
dc.identifier.citationDinç, H. Ö., Karabulut, N., Alaçam, S., Kırkoyun Uysal, H., Daşdemir, F. O., Önel, M., Tuyji Tok, Y., Sirekbasan, S., Agaçfidan, A., Gareayaghi, N., Çakan, H., Eryiğit, Ö. Y. & Kocazeybek, B. (2023). Evaluation of the diagnostic performance of a SARS-CoV-2 and Influenza A/B combo rapid antigen test in respiratory samples. Diagnostics, 13(5), pp. 1-11. https://doi.org/10.3390/diagnostics13050972en_US
dc.identifier.doi10.3390/diagnostics13050972en_US
dc.identifier.endpage12en_US
dc.identifier.issn2075-4418
dc.identifier.issue5en_US
dc.identifier.pmidPMID: 36900116en_US
dc.identifier.scopus2-s2.0-85149754344en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics13050972
dc.identifier.urihttps://hdl.handle.net/20.500.13055/409
dc.identifier.volume13en_US
dc.identifier.wosWOS:000947576000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorEryiğit, Önder Yüksel
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntigen Testsen_US
dc.subjectInfluenza Aen_US
dc.subjectInfluenza Ben_US
dc.subjectRapid Testen_US
dc.subjectSARS-Cov-2en_US
dc.titleEvaluation of the diagnostic performance of a SARS-CoV-2 and Influenza A/B combo rapid antigen test in respiratory samplesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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