Vesicular drug delivery systems: Promising approaches in ocular drug delivery

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dc.authorid0009-0000-3535-4915en_US
dc.authorid0000-0001-6212-2706en_US
dc.authorid0000-0001-5724-9809en_US
dc.authorscopusid57194855634en_US
dc.authorscopusid56585774000en_US
dc.authorwosidP-2971-2019en_US
dc.authorwosidAAD-8509-2020en_US
dc.contributor.authorBatur, Eslim
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2024-04-22T12:43:20Z
dc.date.available2024-04-22T12:43:20Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractOcular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of the eye. Conventional dosage forms often fail to achieve optimal therapeutic outcomes due to poor bioavailability, short retention time, and off-target effects. In recent years, vesicular drug delivery systems have emerged as promising solutions to address these challenges. Vesicular systems, such as liposome, niosome, ethosome, transfersome, and others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, and spanlastics), offer several advantages for ocular drug delivery. These include improved drug bioavailability, prolonged retention time on the ocular surface, reduced systemic side effects, and protection of drugs from enzymatic degradation and dilution by tears. Moreover, vesicular formulations can be engineered for targeted delivery to specific ocular tissues or cells, enhancing therapeutic efficacy while minimizing off-target effects. They also enable the encapsulation of a wide range of drug molecules, including hydrophilic, hydrophobic, and macromolecular drugs, and the possibility of combination therapy by facilitating the co-delivery of multiple drugs. This review examines vesicular drug delivery systems, their advantages over conventional drug delivery systems, production techniques, and their applications in management of ocular diseases.en_US
dc.identifier.citationBatur, E., Özdemir, S., Durgun, M. E., & Özsoy, Y. (2024). Vesicular drug delivery systems: Promising approaches in ocular drug delivery. Pharmaceuticals, 17(4), 1-27. https://doi.org/10.3390/ph17040511en_US
dc.identifier.doi10.3390/ph17040511en_US
dc.identifier.endpage27en_US
dc.identifier.issn1424-8247
dc.identifier.issue4en_US
dc.identifier.pmidPMID: 38675470en_US
dc.identifier.scopus2-s2.0-85191328622en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/ph17040511
dc.identifier.urihttps://hdl.handle.net/20.500.13055/688
dc.identifier.volume17en_US
dc.identifier.wosWOS:001210614500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorBatur, Eslim
dc.institutionauthorÖzdemir, Samet
dc.institutionauthorDurgun, Meltem Ezgi
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticalsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOcular Drug Deliveryen_US
dc.subjectVesicular Systemsen_US
dc.subjectLiposomesen_US
dc.subjectTargeted Deliveryen_US
dc.subjectSustained Releaseen_US
dc.titleVesicular drug delivery systems: Promising approaches in ocular drug deliveryen_US
dc.typeReview Articleen_US
dspace.entity.typePublication

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