Patients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response pattern

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorEsmaeilian, Yashar
dc.contributor.authorYusufoğlu, Sevgi
dc.contributor.authorİltumur, Ece
dc.contributor.authorUğurlu Çimen, Deniz
dc.contributor.authorVatansever, Doğan
dc.contributor.authorTaşkıran, Çağatay
dc.contributor.authorTuran, Volkan
dc.contributor.authorYakın, Kayhan
dc.contributor.authorİncir, Said
dc.contributor.authorUrman, Bülent
dc.contributor.authorÖktem, Özgür
dc.date.accessioned2024-06-24T06:42:52Z
dc.date.available2024-06-24T06:42:52Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractThis study intended to investigate if gynecological cancers compromise ovarian function and reduce the success of assisted reproduction techniques (ART). No clinical and molecular data together is available on this issue for gynecological or other organ cancers. Steroidogenic pathways and DNA damage response characteristics of the granulosa cells retrieved from the 39 gynecological cancer patients were analyzed together with their clinical ART characteristics in comparison to 31 control ART patients. Patients with gynecological malignancies were similar to the control IVF patients for the number of mature oocytes retrieved, fertilization rates and embryo development competency. Molecular analyses of the granulosa cells retrieved from these cancer patients did not detect any perturbations in gonadotropin receptor expression and response, sex steroid production, cholesterol utilization/storage and, DNA damage response pattern in comparison to control IVF patients without cancer. This study provides the first reassuring clinical and molecular combined data set that the presence of gynecological malignancy does not appear to have any detrimental effect on clinical IVF cycle characteristics and ovarian functioning at molecular level.en_US
dc.identifier.citationEsmaeilian, Y., Yusufoğlu, S., İltumur, E., Çimen, D. U., Vatansever, D., Taşkıran, C., Turan, V., Yakın, K., İncir, S., Urman, B., & Öktem, O. (2024). Patients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response pattern. Scientific Reports, 14(1), pp. 1-10. https://doi.org/10.1038/s41598-024-64403-yen_US
dc.identifier.doi10.1038/s41598-024-64403-yen_US
dc.identifier.endpage10en_US
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmidPMID: 38871783en_US
dc.identifier.scopus2-s2.0-85195806128en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-024-64403-y
dc.identifier.urihttps://hdl.handle.net/20.500.13055/722
dc.identifier.volume14en_US
dc.identifier.wosWOS:001249273400006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGynecological Malignanciesen_US
dc.subjectReproductive Parametersen_US
dc.subjectDNA Damageen_US
dc.subjectIVF Patientsen_US
dc.titlePatients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response patternen_US
dc.typeArticleen_US
dspace.entity.typePublication

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