Development of monolithic matrix type transdermal patches containing cinnarizine: physical characterization and permeation studies
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Universidade de São Paulo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
To overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, films based on hydroxypropyl methylcellulose and polyvinylpyrrolidone as matrix-forming polymers were designed. Physical characteristics of transdermal films and drug-excipient compatibility were investigated. Factors affecting in vitro drug release and ex vivo skin penetration and permeation of the drug were studied. It was confirmed that films displayed sufficient flexibility and mechanical strength for application onto the skin for a long time period. Ex vivo penetration experiments gave satisfactory results for transdermal drug delivery through rat skin. The parameters determining good skin penetration were also evaluated. The highest drug permeation rate was obtained with incorporation of Transcutol® (0.102 mg/cm2/h) into the base CNZ formulation, followed by propylene glycol (0.063 mg/cm2/h), menthol (0.045 mg/cm2/h), and glycerin (0.021 mg/cm2/h) as penetration enhancers (p < 0.05). As a result, the developed transdermal patches of CNZ may introduce an alternative treatment for various conditions and diseases such as idiopathic urticarial vasculitis, Ménière’s disease, motion sickness, nausea, and vertigo. Thus, the risk of systemic side effects caused by the drug can be reduced or eliminated.
Açıklama
Anahtar Kelimeler
Cinnarizine, Penetration enhancers, Topical application, Transdermal delivery, Transdermal patches
Kaynak
Brazilian Journal of Pharmaceutical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
58
Sayı
Künye
Damgalı, Ş., Özdemir, S., Kaya, G., Demirkoz, A. B., & Üner, M. (2022). Development of monolithic matrix type transdermal patches containing cinnarizine: Physical characterization and permeation studies. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e19859
