Development of monolithic matrix type transdermal patches containing cinnarizine: physical characterization and permeation studies

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorDamgalı, Şükran
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorKaya, Gizem
dc.contributor.authorBarla Demirkoz, Aslı
dc.contributor.authorÜner, Melike
dc.date.accessioned2022-08-04T10:35:33Z
dc.date.available2022-08-04T10:35:33Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalıen_US
dc.description.abstractTo overcome the problems associated with bioavailability and systemic side effects of the drug by oral administration, monolithic matrix type transdermal patches containing cinnarizine (CNZ) were developed. For this purpose, films based on hydroxypropyl methylcellulose and polyvinylpyrrolidone as matrix-forming polymers were designed. Physical characteristics of transdermal films and drug-excipient compatibility were investigated. Factors affecting in vitro drug release and ex vivo skin penetration and permeation of the drug were studied. It was confirmed that films displayed sufficient flexibility and mechanical strength for application onto the skin for a long time period. Ex vivo penetration experiments gave satisfactory results for transdermal drug delivery through rat skin. The parameters determining good skin penetration were also evaluated. The highest drug permeation rate was obtained with incorporation of Transcutol® (0.102 mg/cm2/h) into the base CNZ formulation, followed by propylene glycol (0.063 mg/cm2/h), menthol (0.045 mg/cm2/h), and glycerin (0.021 mg/cm2/h) as penetration enhancers (p < 0.05). As a result, the developed transdermal patches of CNZ may introduce an alternative treatment for various conditions and diseases such as idiopathic urticarial vasculitis, Ménière’s disease, motion sickness, nausea, and vertigo. Thus, the risk of systemic side effects caused by the drug can be reduced or eliminated.en_US
dc.identifier.citationDamgalı, Ş., Özdemir, S., Kaya, G., Demirkoz, A. B., & Üner, M. (2022). Development of monolithic matrix type transdermal patches containing cinnarizine: Physical characterization and permeation studies. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e19859en_US
dc.identifier.doi10.1590/s2175-97902022e19859en_US
dc.identifier.endpage16en_US
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85135684923en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e19859
dc.identifier.urihttps://hdl.handle.net/20.500.13055/249
dc.identifier.volume58en_US
dc.identifier.wosWOS:000828552300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherUniversidade de São Pauloen_US
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCinnarizineen_US
dc.subjectPenetration enhancersen_US
dc.subjectTopical applicationen_US
dc.subjectTransdermal deliveryen_US
dc.subjectTransdermal patchesen_US
dc.titleDevelopment of monolithic matrix type transdermal patches containing cinnarizine: physical characterization and permeation studiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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