Oocyte cryopreservation with in vitro maturation for fertility preservation in girls at risk for ovarian insufficiency

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorGayete-Lafuente, Sonia
dc.contributor.authorTuran, Volkan
dc.contributor.authorOktay, Kutluk H.
dc.date.accessioned2023-09-18T06:30:29Z
dc.date.available2023-09-18T06:30:29Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractPurpose To assess the feasibility and outcomes of oocyte cryopreservation with in vitro maturation (IVM) in post-pubertal girls undergoing fertility preservation (FP) for primary ovarian insufciency (POI) risk. Methods Ovarian stimulation was performed with an antagonist protocol or progesterone priming. Ultrasound monitoring was performed transabdominally. Oocytes were retrieved transvaginally under IV sedation. Immature oocytes were subjected to IVM for up to 36 h. All MII oocytes were vitrifed. The main outcome measure was the total number of mature oocytes cryopreserved. The secondary outcome was the increase in the mature oocyte yield after IVM. Results Indications for FP included mosaic Turner syndrome (mTS; n=10), malignancy (n=3), and POI risk (n=2). The mean±SD age, antral follicle count (AFC), and AMH levels were 14.2±1.4 years, 8±5.2 and 1.3±1.3 ng/mL. In girls with mTS, the ovarian reserve was low for age (AFC 7.4±4.7 and AMH 1.4±1.6 ng/mL). Oocyte cryopreservation was possible in all girls with a range of 1–27 mature oocytes obtained, even in those who were previously exposed to chemotherapy or with low ovarian reserve, and no surgical complications were encountered. After IVM, the median mature oocyte yield increased signifcantly from 7.5 to 10.5 (p=0.001). Conclusions Oocyte cryopreservation appears to be feasible and safe in girls as young as 12 years of age at risk for POI The utility of IVM increases the yield of cryopreserved mature oocytes. Prior exposure to chemotherapy or low ovarian reserve should not be an automatic reason to exclude these girls from FP consideration.en_US
dc.description.sponsorshipK.O. is funded by NIH HD R01HD053112.en_US
dc.identifier.citationGayete-Lafuente, S., Turan, V., & Oktay, K. H. (2023). Oocyte cryopreservation with in vitro maturation for fertility preservation in girls at risk for ovarian insufficiency. Journal of Assisted Reproduction and Genetics, 40(12), pp. 2777-2785. https://doi.org/10.1007/s10815-023-02932-7en_US
dc.identifier.doi10.1007/s10815-023-02932-7en_US
dc.identifier.endpage2785en_US
dc.identifier.issn1058-0468en_US
dc.identifier.issn1573-7330en_US
dc.identifier.issue12en_US
dc.identifier.pmidPMID: 37715873en_US
dc.identifier.scopus2-s2.0-85171259065en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2777en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-023-02932-7
dc.identifier.urihttps://hdl.handle.net/20.500.13055/540
dc.identifier.volume40en_US
dc.identifier.wosWOS:001069073100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOocyte Cryopreservationen_US
dc.subjectIn Vitro Maturationen_US
dc.subjectFertility Preservationen_US
dc.subjectOvarian Insufciencyen_US
dc.subjectTurner Syndromeen_US
dc.subjectPost-Pubertal Childrenen_US
dc.titleOocyte cryopreservation with in vitro maturation for fertility preservation in girls at risk for ovarian insufficiencyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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