Outcomes of random-start letrozole protocol with PGT-A in women with breast cancer undergoing fertility preservation

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dc.authorscopusid31767766600en_US
dc.authorwosidCDM-6595-2022en_US
dc.contributor.authorTuran, Volkan
dc.contributor.authorGayete-Lafuente, Sonia
dc.contributor.authorBang, Heejung
dc.contributor.authorOktay, Kutluk H.
dc.date.accessioned2023-07-27T08:32:53Z
dc.date.available2023-07-27T08:32:53Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractPURPOSE : To compare the cycle characteristics and outcomes of random-start-controlled ovarian stimulation (RSCOS) protocols to the outcomes of standard-start-controlled ovarian stimulation (SSCOS) cycles and to report the utility of PGT-A in these cycles. Methods: One hundred and seventeen who underwent SSCOS and 39 who underwent RSCOS for oocyte and/or embryo cryopreservation before breast cancer chemotherapy were retrospectively evaluated. Mean number of embryos and blastocyst euploidy rates were the main outcome measures. Results: A majority of RSCOS cycles were initiated in the luteal phase (66.6% luteal vs. 33.3% follicular). While the total dose of gonadotropins was significantly higher in the RSCOS (3720.8 ± 1230.0 vs. 2345.1 ± 803.6 IU; P < 0.001), the mean number of mature oocytes and embryos was similar to SSCOS. However, there was a trend for a higher number of mean embryos with luteal start RSCOS (6.9 ± 2.7 in late follicular start vs. 9.4 ± 4.2 in luteal start, P = 0.08). PGT-A was performed in 48% of the cases that underwent embryo cryopreservation in RSCOS (12 women, mean age = 35.3 ± 4.1; 87 blastocysts), revealing a euploidy rate of 36.2 ± 22.3% per patient. This rate was comparable to a 45% aneuploidy rate from similarly aged published data. Of the 7 RSCOS patients who returned for frozen embryo transfer, 5 delivered and one has an ongoing pregnancy, while in SSCOS, 18 out of 40 cycles resulted in live birth. Conclusion: Our data suggests that RSCOS fertility preservation cycle outcomes are similar to those with SSCOS and result in age-appropriate euploidy rates.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) RO1 HD053112en_US
dc.identifier.citationTuran, V., Gayete-Lafuente, S., Bang, H., & Oktay, K. H. (2023). Outcomes of random-start letrozole protocol with PGT-A in women with breast cancer undergoing fertility preservation. Journal of Assisted Reproduction and Genetics, 40(10), pp. 2401-2408 https://doi.org/10.1007/s10815-023-02882-0en_US
dc.identifier.doi10.1007/s10815-023-02882-0en_US
dc.identifier.endpage2408en_US
dc.identifier.issn1573-7330
dc.identifier.issn1058-0468
dc.identifier.issue10en_US
dc.identifier.pmidPMID: 37488389en_US
dc.identifier.scopus2-s2.0-85165427132en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2401en_US
dc.identifier.urihttps://doi.org/10.1007/s10815-023-02882-0
dc.identifier.urihttps://hdl.handle.net/20.500.13055/508
dc.identifier.volume40en_US
dc.identifier.wosWOS:001034502400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherSpringer/Plenum Pressen_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectEmbryoen_US
dc.subjectLetrozoleen_US
dc.subjectPreimplantation Genetic Testingen_US
dc.subjectRandom-Start-Controlled Ovarian Stimulationen_US
dc.titleOutcomes of random-start letrozole protocol with PGT-A in women with breast cancer undergoing fertility preservationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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