Thermoresponsive sol–gel system incorporating oleuropein-rich olive leaf extract for enhanced wound healing and antibiofilm activity

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dc.authorid0000-0003-0113-6850
dc.authorid0000-0001-6212-2706
dc.authorid0000-0003-1166-3101
dc.authorid0000-0002-6803-494X
dc.authorid0000-0002-6502-528X
dc.authorid0000-0002-5146-0811
dc.authorid0000-0001-7112-923X
dc.authorid0000-0001-5456-8636
dc.authorid0009-0007-4262-2501
dc.authorid0000-0001-7928-1666
dc.contributor.authorAlparslan, Levent
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorKaracan, Burak
dc.contributor.authorTorkay, Gülşah
dc.contributor.authorBal Öztürk, Ayça
dc.contributor.authorTutar, Ömer Faruk
dc.contributor.authorÖzcan Bülbül, Ece
dc.contributor.authorSardaş, Semra
dc.contributor.authorKala, Zübeyde Merve
dc.contributor.authorÖzalp, Yıldız
dc.date.accessioned2026-04-19T09:43:32Z
dc.date.available2026-04-19T09:43:32Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractOleuropein, the principal secoiridoid phenolic compound of olive leaves (Olea europaea L.), is recognized for its broad-spectrum antimicrobial, antibiofilm, antioxidant, and tissue regenerative properties. However, its effective local therapeutic application remains chal lenging due to rapid clearance from the site of administration and limited residence time. In this study, an oleuropein-rich aqueous olive leaf extract was incorporated into a ther moresponsive sol–gel delivery system designed for localized application. The formulation was engineered to remain in a low-viscosity sol state at room temperature and to undergo a temperature-triggered sol-to-gel transition near physiological temperature (~33 ◦C), en abling in situ gel formation. Oleuropein content was quantified using a validated HPLC method, and the formulation was characterized with respect to physicochemical parame ters, thermoreversible gelation behavior, particle size distribution, mechanical properties, and spreadability. Biological performance was evaluated through in vitro cytocompati bility (MTT assay), fibroblast migration (scratch assay), and collagen deposition (Sirius Red staining) in L929 fibroblasts, as well as antibiofilm activity against representative Gram-positive and Gram-negative bacterial strains. The developed sol–gel system demon strated stable physicochemical characteristics, rapid and reversible thermogelation, suitable mechanical and spreading properties, concentration-dependent inhibition of biofilm for mation, and acceptable cytocompatibility within the tested concentration range. Notably, the formulation supported fibroblast viability and collagen-associated responses at opti mized concentrations. Overall, the results indicate that the proposed thermoresponsive sol–gel formulation represents a promising strategy for the localized delivery of oleuropein rich olive leaf extract, combining physicochemical stability with dual wound-healing and antibiofilm functionality.
dc.identifier.citationAlparslan, L., Özdemir, S., Karacan, B., Torkay, G., Bal Öztürk, A., Tutar, Ö. F., Özcan Bülbül, ., Sardaş, S., Kala, Z. M., & Özalp, Y. (2026). Thermoresponsive sol–gel system incorporating oleuropein-rich olive leaf extract for enhanced wound healing and antibiofilm activity. Gels, 12(4), pp. 1-24. https://doi.org/10.3390/gels12040307
dc.identifier.doi10.3390/gels12040307
dc.identifier.endpage26
dc.identifier.issn2310-2861
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/gels12040307
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1425
dc.identifier.volume12
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorÖzdemir, Samet
dc.institutionauthorid0000-0001-6212-2706
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofGels
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOleuropein
dc.subjectSol–Gel System
dc.subjectAntibiofilm Activity
dc.subjectWound Healing
dc.subjectTopical Delivery
dc.titleThermoresponsive sol–gel system incorporating oleuropein-rich olive leaf extract for enhanced wound healing and antibiofilm activity
dc.typeArticle
dspace.entity.typePublication

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