Solid lipid nanoparticles based dry powder inhalers for enhanced drug delivery against lung diseases

Basit Öğe Kaydı
dc.authorid0009-0000-2639-8158
dc.authorid0000-0001-6915-0283
dc.authorid0000-0002-9110-3704
dc.contributor.authorÖnel, Çağla
dc.contributor.authorPirinçci Tok, Yağmur
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2026-10-14T06:44:09Z
dc.date.available2026-10-14T06:44:09Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractThe global incidence of lung diseases associated with high mortality and morbidity rates is projected to rise in the coming years. Conventional therapies face limitations such as low bioavailability and systemic side effects with oral administration, as well as poor patient compliance and frequent dosing with traditional inhalers. These shortcomings have created an urgent need for novel pulmonary drug delivery systems. In recent years, nanoparticulate drug carriers have gained significance for their potential to enable targeted lung delivery and reduced dosing frequency. Among them, solid lipid nanoparticles (SLNs) have attracted considerable attention due to their biocompatible and biodegradable structures, controlled release capabilities, organic solvent-free production processes and favorable aerodynamic behavior. This review provides a comprehensive per spective to guide the rational design of SLN-based dry powder inhaler (DPI) systems by integrating formulation strategies, production techniques, surface functionalization, and DPI development, with the goal of enhancing therapeutic outcomes in respiratory diseases such as cancer, infections, chronic obstructive pulmonary disease, and cystic fibrosis.
dc.description.sponsorshipThis study was supported by Istanbul University Scientific Research Project Units, grant number TYL-2025-42465. Bu çalışma, İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi tarafından TYL-2025-42465 numaralı proje kapsamında desteklenmiştir.
dc.identifier.citationÖnel, Ç., Pirinçci Tok, Y., & Özsoy, Y. (2026). Solid lipid nanoparticles based dry powder inhalers for enhanced drug delivery against lung diseases. AAPS PharmSciTech, 27(7), pp. 1-28. https://doi.org/10.1208/s12249-026-03513-4
dc.identifier.doi10.1208/s12249-026-03513-4
dc.identifier.endpage28
dc.identifier.issn1530-9932
dc.identifier.issue7
dc.identifier.pmidPMID: 42717150
dc.identifier.scopus2-s2.0-105049868191
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1208/s12249-026-03513-4
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1670
dc.identifier.volume27
dc.identifier.wosWOS:001871925700003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorPirinçci Tok, Yağmur
dc.institutionauthorid0000-0001-6915-0283
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofAAPS PharmSciTech
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDry Powder Inhaler
dc.subjectNanotechnology
dc.subjectPulmonary Targeting
dc.subjectSolid Lipid Nanoparticles
dc.titleSolid lipid nanoparticles based dry powder inhalers for enhanced drug delivery against lung diseases
dc.typeReview Article
dspace.entity.typePublication

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