Characterization of bovine bone marrow derived mesenchymal stem cells and immunostaining of differentiated neurospheres

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dc.authorid0000-0003-4470-7465en_US
dc.authorscopusid57212196761en_US
dc.authorwosidAAK-6831-2021en_US
dc.contributor.authorDikmen, Tayfun
dc.contributor.authorÖzden Akkaya, Özlem
dc.contributor.authorNawaz, Shah
dc.contributor.authorErdoğan, Metin
dc.date.accessioned2023-07-09T11:53:11Z
dc.date.available2023-07-09T11:53:11Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractStem cell differentiation has been a key element for the therapeutical applications for various disorders. The novel anti-inflammatory and angiogenic findings and potential applications for both autologous and allogenic studies have emphasized about the usage of mesenchymal stem cells in the clinical trials. The neurosphere differentia-tion studies and their role for peripheral nerve injuries have gained momentum recently. Following study emphasized on the isolation of stem cells from bovine bone marrow and characterization of their mesenchymal potential by PCR followed by their differentiation into mesodermal lineages and into neurospheres under specific induction media. The generated neurospheres were further investigated for their potential expressions of neuroprogenitor markers Sox2, Nestin and neurofilament protein β-III Tubulin by immunofluorescence staining. The results of following study high-light the unique potential of bone marrow derived mesenchymal stem cells for translational research and regenerative therapy in nervous tissue injuries.en_US
dc.identifier.citationDikmen, T., Özden Akkaya, Ö., Nawaz, S., & Erdoğan, M. (2023). Characterization of bovine bone marrow derived mesenchymal stem cells and immunostaining of differentiated neurospheres. Journal of the Hellenic Veterinary Medical Society, 74(2), pp. 5599-5608. https://doi.org/10.12681/jhvms.28390en_US
dc.identifier.doi10.12681/jhvms.28390en_US
dc.identifier.endpage5608en_US
dc.identifier.issn2585-3724
dc.identifier.issn1792-2720
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85165350953en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage5599en_US
dc.identifier.urihttps://doi.org/10.12681/jhvms.28390
dc.identifier.urihttps://hdl.handle.net/20.500.13055/494
dc.identifier.volume74en_US
dc.identifier.wosWOS:001026699900011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorDikmen, Tayfun
dc.language.isoenen_US
dc.publisherHellenic Veterinary Medical Societyen_US
dc.relation.ispartofJournal of the Hellenic Veterinary Medical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectß-III Tubulinen_US
dc.subjectBone Marrow Derived Stem Cellsen_US
dc.subjectBovineen_US
dc.subjectNestinen_US
dc.subjectNeurospheresen_US
dc.subjectSox2en_US
dc.titleCharacterization of bovine bone marrow derived mesenchymal stem cells and immunostaining of differentiated neurospheresen_US
dc.typeArticleen_US
dspace.entity.typePublication

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