Association of germline BRCA pathogenic variants with diminished ovarian reserve: A meta-analysis of individual patient-level data

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dc.authorscopusid31767766600en_US
dc.contributor.authorTuran, Volkan
dc.contributor.authorLambertini, Matteo
dc.contributor.authorLee, Dong-Yun
dc.contributor.authorWang, Erica
dc.contributor.authorClatot, Florian
dc.contributor.authorKarlan, Beth Y.
dc.contributor.authorDemeestere, Isabelle
dc.contributor.authorBang, Heejung
dc.contributor.authorOktay, Kutluk
dc.date.accessioned2021-12-08T07:48:35Z
dc.date.available2021-12-08T07:48:35Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractPURPOSE: To determine whether germline BRCA (gBRCA) pathogenic variants are associated with decreased ovarian reserve. MATERIALS AND METHODS: An individual patient-level data meta-analysis was performed using five data sets on 828 evaluable women who were tested for gBRCA. Of those, 250 carried gBRCA, whereas 578 had tested negative and served as controls. Of the women with gBRCA, four centers studied those affected with breast cancer (n = 161) and one studied unaffected individuals (n = 89). The data were adjusted for the center, age, body mass index, smoking, and oral contraceptive pill use before the final analysis. Anti-Müllerian hormone (AMH) levels in affected women were drawn before presystemic therapy. RESULTS: The mean age of women with versus without gBRCA1/2 (34.1 ± 4.9 v 34.3 ± 4.8 years; P = .48) and with gBRCA1 versus gBRCA2 (33.7 ± 4.9 v 34.6 ± 4.8 years; P = .16) was similar. After the adjustments, women with gBRCA1/2 had significantly lower AMH levels compared with controls (23% lower; 95% CI, 4 to 38; P = .02). When the adjusted analysis was limited to affected women (157 with gBRCA v 524 without, after exclusions), the difference persisted (25% lower; 95% CI, 9 to 38; P = .003). The serum AMH levels were lower in women with gBRCA1 (33% lower; 95% CI, 12 to 49; P = .004) but not gBRCA2 compared with controls (7% lower; 95% CI, 31% lower to 26% higher; P = .64). CONCLUSION: Young women with gBRCA pathogenic variants, particularly those affected and with gBRCA1, have lower serum AMH levels compared with controls. They may need to be preferentially counseled about the possibility of shortened reproductive lifespan because of diminished ovarian reserve.en_US
dc.identifier.citationTuran, V., Lambertini, M., Lee, D.-Y., Wang, E., Clatot, F., Karlan, B. Y., Demeestere, I., Bang, H., & Oktay, K. (20 Jun 2021). Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data. Journal of Clinical Oncology, 39(18), pp. 2016–2024. https://doi.org/10.1200/jco.20.02880en_US
dc.identifier.doi10.1200/JCO.20.02880en_US
dc.identifier.endpage2024en_US
dc.identifier.issue18en_US
dc.identifier.pmid33891474en_US
dc.identifier.scopus2-s2.0-85107593813en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2016en_US
dc.identifier.urihttps://ascopubs.org/doi/10.1200/JCO.20.02880
dc.identifier.urihttps://hdl.handle.net/20.500.13055/72
dc.identifier.volume39en_US
dc.identifier.wosWOS:000708045700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorTuran, Volkan
dc.language.isoenen_US
dc.publisherAmerican Society of Clinical Oncologyen_US
dc.relation.ispartofJournal of Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation of germline BRCA pathogenic variants with diminished ovarian reserve: A meta-analysis of individual patient-level dataen_US
dc.typeArticleen_US
dspace.entity.typePublication

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