Staphylococcus aureus as a signature species of skin microbiome in actinic keratosis and squamous cell carcinoma: A narrative review

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dc.authorid0000-0001-6295-211X
dc.authorid0000-0002-9155-621X
dc.authorid0009-0000-2787-2640
dc.authorid0000-0003-3058-9971
dc.contributor.authorDuman, Nilay
dc.contributor.authorOraloğlu, Göktürk
dc.contributor.authorEce, Deniz
dc.contributor.authorCaner, Ayşe
dc.date.accessioned2025-04-30T08:33:01Z
dc.date.available2025-04-30T08:33:01Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractCutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer and the second most common type of nonmelanoma skin cancer. Actinic keratosis (AK) is a premalignant lesion that can progress to cSCC over time. AK and cSCC are associated with microbial dysbiosis and an increased abundance of the bacterium Staphylococcus aureus. Although AK and cSCC are highly colonized with S. aureus, a bacterium of the skin microbiota, it is not yet known whether this bacterium is associated with cancer development. Here, we analyze the studies on the relationship between S. aureus and keratinocytic skin neoplasia, evaluating the contribution of S. aureus to the development and prognosis of cSCC and AK lesions. The overabundance of S. aureus and the compounds secreted by this bacterium can induce cancer‑promoting changes in skin cells. The presence of high amounts of certain S. aureus strains in premalignant skin lesions may constitute a protumorigenic stimulus by inducing oxidative stress and DNA damage and downregulating DNA repair mechanisms. S. aureus associated with AK and cSCC can trigger keratinocytes to produce inflammatory cytokines typically upregulated in cSCC. These circumstances also suggest a potential specific involvement of S. aureus in the progression from AK to cSCC.
dc.identifier.citationDuman, N., Oraloğlu, G., Ece, D., & Caner, A. (2025). Staphylococcus aureus as a signature species of skin microbiome in actinic keratosis and squamous cell carcinoma: A narrative review. Dermatologica Sinica, pp. 1-7. https://doi.org/10.4103/ds.DS-D-24-00248
dc.identifier.doi10.4103/ds.DS-D-24-00248
dc.identifier.endpage7
dc.identifier.issn1027-8117
dc.identifier.issn2223-330X
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.4103/ds.DS-D-24-00248
dc.identifier.urihttps://hdl.handle.net/20.500.13055/965
dc.identifier.wosqualityQ2
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorOraloğlu, Göktürk
dc.institutionauthorid0000-0002-9155-621X
dc.language.isoen
dc.publisherWolters Kluwer
dc.relation.ispartofDermatologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectActinic Keratosis
dc.subjectCancer
dc.subjectCutaneous Squamous Cell Carcinoma
dc.subjectSkin Microbiome
dc.subjectStaphylococcus Aureus
dc.titleStaphylococcus aureus as a signature species of skin microbiome in actinic keratosis and squamous cell carcinoma: A narrative review
dc.typeArticle
dspace.entity.typePublication

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