MAFLD: A comprehensive review of the link between metabolic dysfunction and cardiovascular risk

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dc.authorid0000-0002-1237-8428
dc.authorid0000-0001-8365-5712
dc.authorid0000-0001-8145-1900
dc.authorid0000-0002-8909-2102
dc.contributor.authorM. Mostafa, Alaa
dc.contributor.authorPan, Ziyan
dc.contributor.authorYu, Ming-Lung
dc.contributor.authorÖrmeci, Necati
dc.contributor.authorFouad, Yasser
dc.contributor.authorEslam, Mohammed
dc.date.accessioned2025-08-21T15:31:43Z
dc.date.available2025-08-21T15:31:43Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractMetabolic dysfunction-associated fatty liver disease (MAFLD) affects over 30% of the global population. It is a multisystem condition with a strong association with cardiovascular disease (CVD), the leading cause of mortality worldwide. Key shared mechanisms, including insulin resistance, systemic inflammation, oxidative stress, and genetic predisposition, couple MAFLD with increased risks of coronary artery disease, ischemic heart disease, and heart failure. Early detection via non-invasive imaging and biomarkers is crucial for effective risk stratification. Management strategies emphasize lifestyle modifications and the development of targeted pharmacotherapies addressing metabolic and inflammatory pathways. Understanding the interconnected pathogenic mechanisms facilitates personalized interventions to reduce morbidity and improve long-term outcomes. A multidisciplinary approach remains essential to prevent and manage the cardiovascular implications of MAFLD.
dc.description.sponsorshipME is supported by a National Health and Medical Research Council of Australia (NHMRC) investigator and ideas grants (AAP2008983 and APP2001692). MLY is supported by the “Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung” from The Featured Areas Research Centre Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan, and Center for Liquid Biopsy and Cohort Research KMU-TC109B05, Kaohsiung Medical University. ME, Avustralya Ulusal Sağlık ve Tıbbi Araştırma Konseyi (NHMRC) araştırmacı ve fikir hibeleri (AAP2008983 ve APP2001692) tarafından desteklenmektedir. MLY ise Tayvan Eğitim Bakanlığı (MOE) tarafından yürütülen Yüksek Öğrenim Filiz Projesi kapsamındaki Öne Çıkan Alanlar Araştırma Merkezi Programı kapsamındaki "Metabolik İlişkili Yağlı Karaciğer Hastalığı Mükemmeliyet Merkezi, Kaohsiung Ulusal Sun Yat-sen Üniversitesi" ve Kaohsiung Tıp Üniversitesi Sıvı Biyopsi ve Kohort Araştırma Merkezi (KMU-TC109B05) tarafından desteklenmektedir.
dc.identifier.citationM. Mostafa, A., Pan, Z., Yu, M. L., Örmeci, N., Fouad, Y., & Eslam, M. (2025). MAFLD: A comprehensive review of the link between metabolic dysfunction and cardiovascular risk. Hepatic Medicine: Evidence and Research, 17, pp. 75-90. https://doi.org/10.2147/HMER.S506402
dc.identifier.doi10.2147/HMER.S506402
dc.identifier.endpage90
dc.identifier.issn1179-1535
dc.identifier.pmidPMID: 40860752
dc.identifier.startpage75
dc.identifier.urihttps://doi.org/10.2147/HMER.S506402
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1084
dc.identifier.volume17
dc.identifier.wosWOS:001552539100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorÖrmeci, Necati
dc.institutionauthorid0000-0002-8909-2102
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofHepatic Medicine: Evidence and Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFatty Liver
dc.subjectCardiometabolic Risk
dc.subjectMetabolic Dysfunction
dc.subjectPharmacotherapy
dc.titleMAFLD: A comprehensive review of the link between metabolic dysfunction and cardiovascular risk
dc.typeReview Article
dspace.entity.typePublication

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