Predictors of re-biopsy in percutaneous musculoskeletal tumor biopsies: A single-center retrospective cohort study

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dc.authorid0000-0003-3494-6163
dc.authorid0000-0001-7108-9864
dc.authorid0000-0001-7825-8296
dc.authorid0000-0001-8074-4672
dc.authorid0009-0003-7984-1231
dc.authorid0000-0002-1785-4462
dc.contributor.authorYücesan, Ali
dc.contributor.authorArıkan, Yavuz
dc.contributor.authorDoğukan, Fatih Mert
dc.contributor.authorMutlu, İlhan Nahit
dc.contributor.authorToy, Serdar
dc.contributor.authorAtan, Tamer
dc.contributor.authorÖzer, Devrim
dc.date.accessioned2026-04-19T11:05:19Z
dc.date.available2026-04-19T11:05:19Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.description.abstractPurpose: This study aimed to evaluate the diagnostic success of percutaneous biopsies performed for suspected mus culoskeletal tumors and to identify clinical, anatomical, and procedural factors associated with the need for repeat biopsy (re-biopsy). The secondary objective was to assess the impact of multidisciplinary team (MDT) evaluation on reducing unnecessary re-biopsy procedures. Methods: A total of 565 patients (331 bone, 234 soft tissue lesions) who underwent percutaneous biopsy for suspected musculoskeletal tumors between 2020 and 2024 were retrospectively analyzed. Diagnostic success was defined as a biopsy yielding a definitive histopathological diagnosis sufficient to guide treatment planning without additional tissue sampling. Predictive factors including lesion size, depth, location, and performing specialty were evaluated using univariate and multivariate logistic regression analyses. Results: The initial diagnostic yield was 65.5%. Multivariate analysis revealed that lesion width <2 cm (OR = 2.01; 95% CI, 1.19–3.39; p = 0.009) and biopsy performed by an interventional radiologist (compared to an orthopedic surgeon) (OR = 5.25; 95% CI, 2.83–9.74; p < 0.001) were independent predictors of re-biopsy recommendation. Among 72 patients recommended for re-biopsy, MDT evaluation averted the need for a second procedure in 38 cases (52.8%). Conclusion: Smaller lesion size (<2 cm) and the medical specialty performing the biopsy were independent predictors of re-biopsy recommendation, with the latter likely reflecting systematic differences in case complexity and procedural environment rather than operator skill. Structured MDT evaluation significantly reduced unnecessary repeat procedures.
dc.identifier.citationYücesan, A., Arıkan, Y., Doğukan, F. M., Mutlu, İ. N., Toy, S., Atan, T., & Özer, D. (2026). Predictors of re-biopsy in percutaneous musculoskeletal tumor biopsies: A single-center retrospective cohort study. Journal of Orthopaedic Surgery, 34(1), pp. 1-10. https://doi.org/10.1177/10225536261439408
dc.identifier.doi10.1177/10225536261439408
dc.identifier.endpage10
dc.identifier.issn1022-5536
dc.identifier.issn2309-4990
dc.identifier.issue1
dc.identifier.pmidPMID: 41937504
dc.identifier.scopus2-s2.0-105034888767
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1177/10225536261439408
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1426
dc.identifier.volume34
dc.identifier.wosWOS:001733701900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorArıkan, Yavuz
dc.institutionauthorid0000-0001-7108-9864
dc.language.isoen
dc.publisherSAGE Publications
dc.relation.ispartofJournal of Orthopaedic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMusculoskeletal Neoplasms
dc.subjectBiopsy
dc.subjectNeedle
dc.subjectDiagnostic Yield
dc.subjectInterventional Radiology
dc.subjectOrthopedic Oncology
dc.subjectMultidisciplinary Tumor Board
dc.subjectRe-Biopsy
dc.subjectJamshidi Needle
dc.subjectCore Needle Biopsy
dc.subjectRetrospective Cohort Study
dc.titlePredictors of re-biopsy in percutaneous musculoskeletal tumor biopsies: A single-center retrospective cohort study
dc.typeArticle
dspace.entity.typePublication

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