Insufficient impact of the aldose reductase inhibitor cemtirestat on the skeletal system in type 2 diabetic rat model

Basit Öğe Kaydı
dc.authorid0000-0003-1889-026X
dc.authorid0000-0001-6278-6684
dc.authorid0000-0002-8491-0399
dc.authorid0000-0002-7186-4282
dc.authorid0000-0002-2642-7737
dc.authorid0000-0003-0542-8471
dc.authorid0000-0002-4376-2748
dc.authorid0000-0002-6493-9880
dc.authorid0000-0003-4470-7465
dc.contributor.authorMartiniakova, Monika
dc.contributor.authorPrnova, Marta Soltesova
dc.contributor.authorKovacova, Veronika
dc.contributor.authorMondockova, Vladimira
dc.contributor.authorSvik, Karol
dc.contributor.authorLondzin, Piotr
dc.contributor.authorFolwarczna, Joanna
dc.contributor.authorOmelka, Radoslav
dc.contributor.editorDikmen, Tayfun
dc.date.accessioned2025-11-24T11:54:59Z
dc.date.available2025-11-24T11:54:59Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractCemtirestat, a multi-target drug combining aldose reductase inhibition with antiox idant properties, is considered a promising therapeutic agent for chronic diabetic complications. Current evidence suggests that long-standing diabetes adversely affects skeletal health, leading to diabetic bone disease. As the impact of cemtirestat on the skeletal system in an animal model of type 2 diabetes mellitus (T2DM) is still unknown, our study first investigated its effect on impaired bone health in Zucker dia betic fatty (ZDF) rats. Adult rats were divided into four groups: L (untreated lean ZDF rats), D (untreated obese ZDF rats), DT2.5 (obese ZDF rats treated with 2.5mg/kg/ day cemtirestat), and DT7.5 (obese ZDF rats treated with 7.5mg/kg/day cemtirestat), with cemtirestat treatment lasting 2 months. Group D had increased levels of plasma glucose, insulin, triglycerides, glycated hemoglobin, total cholesterol, alkaline phos phatase, alanine aminotransferase, C-terminal telopeptide of type 1 collagen, greater body weight, femoral weight, structure model index, reduced cortical bone volume fraction, cortical bone thickness, trabecular bone volume fraction, and trabecular thickness compared to group L. Cemtirestat supplementation only elevated plasma phosphate levels in group DT2.5, trabecular bone volume fraction and trabecu lar thickness in group DT7.5, but the treatment had no effect on other parameters demonstrated in ZDF rats by macroscopic analysis, micro-CT cortical bone analysis, and mechanical testing. These findings indicate that the efficacy of cemtirestat in restoring deteriorated bone health caused by T2DM is not substantiated due to its insufficient effect on the skeletal system in the ZDF rat model.
dc.identifier.citationMartiniakova, M., Prnova, M. S., Kovacova, V., Mondockova, V., Svik, K., Londzin, P., Folwarczna, J., & Omelka, R. (2025). Insufficient impact of the aldose reductase inhibitor cemtirestat on the skeletal system in type 2 diabetic rat model. Plos One, 20(11), pp. 1-14. https://doi.org/10.1371/journal.pone.0336508
dc.identifier.doi10.1371/journal.pone.0336508
dc.identifier.endpage14
dc.identifier.issn1932-6203
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0336508
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1203
dc.identifier.volume20
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInsufficient impact of the aldose reductase inhibitor cemtirestat on the skeletal system in type 2 diabetic rat model
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
Ä°sim:
Tam Metin / Full Text
Boyut:
3.91 MB
Biçim:
Adobe Portable Document Format
Ä°ndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
Ä°sim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
Ä°ndir

Koleksiyon

Temel Tıp Bilimleri Bölümü Koleksiyonu