Single session anodal transcranial direct current stimulation on different cortical areas: Effects on pain modulation in healthy subjects

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dc.authorid0000-0001-9832-8263en_US
dc.authorscopusid6507675504en_US
dc.authorwosidJ-2573-2018en_US
dc.contributor.authorTuna Erdoğan, Ezgi
dc.contributor.authorKüçük, Zeynep
dc.contributor.authorEskikurt, Gökçer
dc.contributor.authorKurt, Adnan
dc.contributor.authorErmutlu, Numan
dc.contributor.authorKaramürsel, Sacit
dc.date.accessioned2023-01-24T13:47:47Z
dc.date.available2023-01-24T13:47:47Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractTranscranial direct current stimulation (tDCS) studies in healthy volunteers have shown conflicting results in terms of modulation in pain thresholds. The aim of this study was to investigate how single session anodal tDCS and modulated tDCS (mtDCS) of distinct cortical areas affected pain and perception thresholds in healthy participants. Five different stimulation conditions were applied at different cortical sites to 20 healthy volunteers to investigate the effects of tDCS and mtDCS (20 Hz) on pain and perception thresholds. TDCS over the motor cortex (M1), mtDCS over the motor cortex, tDCS over the dorsolateral prefrontal cortex (DLPFC), mtDCS of the DLPFC, and mtDCS over the occipital cortex were the stimulation conditions. All of the stimulations were anodal. The stimulations were given in a randomized order at 20-minute intervals. For comparison, electrical pain and perception thresholds were obtained from the right middle finger before and during the tDCS. After each measurement, participants were asked to give a score to their pain. In repeated measures analysis of variance (RM-ANOVA) test, the Condition x Time interaction showed no significant influence on changes in pain, perception thresholds, and pain scores (p = .48, p = .89, and p = .50, respectively). However, regardless of the condition types, there was a significant difference in pain and perceptual thresholds during tDCS (p = .01, p = .025, respectively). Our findings did not support difference in pain and perception modulation by a single session anodal tDCS over M1 and DLPFC compared to the occipital cortex in healthy volunteers. The increase in all thresholds during tDCS, irrespective of conditions, and peripheral sensations, including an active control group, taken together, suggest a placebo effect of active tDCS. Future studies about pain and perception in healthy subjects should consider the level of experimental pain and a strong placebo effect.en_US
dc.identifier.citationTuna Erdoğan, E., Küçük, Z., Eskikurt, G., Kurt, A., Ermutlu, N. & Karamürsel, S. (2022). Single session anodal transcranial direct current stimulation on different cortical areas: Effects on pain modulation in healthy subjects. Journal of Psychophysiology, 37(2), pp. 101-109. https://doi.org/10.1027/0269-8803/a000311en_US
dc.identifier.doi10.1027/0269-8803/a000311en_US
dc.identifier.endpage109en_US
dc.identifier.issn0269-8803
dc.identifier.issn2151-2124
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85140362407en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage101en_US
dc.identifier.urihttps://doi.org/10.1027/0269-8803/a000311
dc.identifier.urihttps://hdl.handle.net/20.500.13055/379
dc.identifier.volume37en_US
dc.identifier.wosWOS:000863748700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.indekslendigikaynak.otherSSCI - Social Science Citation Indexen_US
dc.institutionauthorErmutlu, Numan
dc.language.isoenen_US
dc.publisherHogrefe Publishingen_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/113S302
dc.relation.ispartofJournal of Psychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTranscranial Direct Current Stimulationen_US
dc.subjectPerception Thresholden_US
dc.subjectPain Thresholden_US
dc.subjectNeuromodulationen_US
dc.subjectHealthy Volunteersen_US
dc.titleSingle session anodal transcranial direct current stimulation on different cortical areas: Effects on pain modulation in healthy subjectsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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