Glycosylated zinc(II) phthalocyanine photosensitizer: Synthesis, photophysical properties and in vitro photodynamic activity on breast cancer cell line

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dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.authorwosidCJT-9277-2022en_US
dc.contributor.authorBilen, Başak Sezgi
dc.contributor.authorÖzçeşmeci, Mukaddes
dc.contributor.authorKoçyiğit, Nilüfer
dc.contributor.authorElgün, Tuğba
dc.contributor.authorYurttaş, Asiye Gök
dc.contributor.authorHamuryudan, Esin
dc.date.accessioned2023-10-05T06:19:58Z
dc.date.available2023-10-05T06:19:58Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.description.abstractBreast cancer is a common type of cancer among women worldwide. Triple negative breast cancer is a highly aggressive subtype of breast cancer and accounts for approximately 24% of all identified breast cancer cases. In triple negative breast cancer, the therapeutic approach options are very limited. In this study, 4-[2′,3′,5′,6′-tetrafluoro-4′-(1,2:5,6-di-O-isopropylidene-α-d-glucofuranosyl)benzyloxy]phthalonitrile and its peripherally tetra substituted zinc phthalocyanine derivatives are reported for the first time. Photophysical and photochemical properties of the glycosylated zinc(II) phthalocyanine derivative were investigated for its suitability for use as a photosensitizer in photodynamic therapy. The fluorescence (ΦF: 0.089), singlet oxygen (Φd: 0.45) and photodegradation quantum yields (Φ∆: 6.07×10−5) of this compound were carried out in N,N-dimethylformamide. The in vitro photodynamic activities of this compound against MDA-MB-231 cells were also studied. Cytotoxicity analysis in this cell lines was performed by MTT (3-(4,5-dimethylthiazol-2-yl) method. Cytotoxicity test was applied on cell lines of MDA-MB-231 and HUVEC. The IC50 value is determined for glycosylated zinc(II) Pc derivative.en_US
dc.description.sponsorshipIstanbul Technical Universityen_US
dc.identifier.citationBilen, B. S., Özçeşmeci, M., Koçyiğit, N., Elgün, T., Yurttaş, A. G., & Hamuryudan, E. (2024). Glycosylated zinc(II) phthalocyanine photosensitizer: Synthesis, photophysical properties and in vitro photodynamic activity on breast cancer cell line. Journal of Molecular Structure, 1295, pp. 1-9. https://doi.org/10.1016/j.molstruc.2023.136688en_US
dc.identifier.doi10.1016/j.molstruc.2023.136688en_US
dc.identifier.endpage9en_US
dc.identifier.issn0022-2860
dc.identifier.scopus2-s2.0-85171766616en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2023.136688
dc.identifier.urihttps://hdl.handle.net/20.500.13055/552
dc.identifier.volume1295en_US
dc.identifier.wosWOS:001082296500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorYurttaş, Asiye Gök
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectMDA-MB-231en_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectPhthalocyanineen_US
dc.subjectSinglet Oxygenzincen_US
dc.titleGlycosylated zinc(II) phthalocyanine photosensitizer: Synthesis, photophysical properties and in vitro photodynamic activity on breast cancer cell lineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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