The effect of radiofrequency exposure on the cytotoxic activity of sunitinib and a novel sunitinib-class compound 4, in colorectal cancer cells

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dc.authorid0000-0002-2780-1196
dc.authorid0000-0002-1401-4863
dc.authorid0000-0001-5625-0189
dc.authorid0000-0002-0588-2212
dc.authorid0000-0003-4677-2236
dc.authorid0000-0001-7878-9994
dc.contributor.authorErol Bozkurt, Ayşe
dc.contributor.authorSüleymanoğlu, Mediha
dc.contributor.authorCinek, Tuğçe
dc.contributor.authorKarali, Nilgün
dc.contributor.authorBallıkaya, Sedat
dc.contributor.authorİyikesici, Mehmet Salih
dc.contributor.authorKuruca, Serap
dc.date.accessioned2026-08-01T13:16:47Z
dc.date.available2026-08-01T13:16:47Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractAchieving optimal therapeutic efficacy in colorectal cancer (CRC) remains challenging, highlighting the need for novel treatment strategies. This study evaluated whether radiofre quency (RF) hyperthermia enhances the anticancer effects of sunitinib malate and a newly synthesized tyrosine kinase (TK) inhibitor (compound 4). HCT116 CRC cells and BEAS-2B normal epithelial cells were treated with increasing concentrations of both agents in the presence or absence of RF exposure using a mobile RF device. Cell viability and death were assessed by MTT assay and flow cytometry (Annexin V/PI). RF exposure was associated with reduced viability and increased cell death in HCT116 cells (p < 0.05). Flow cytometric analysis confirmed that RF exposure may contribute to the observed reduction in viability. Notably, the findings suggest a possible beneficial contribution of RF hyperthermia to the observed cytotoxic effects, particularly near the IC50 concentration. In contrast, BEAS-2B cells maintained high viability with no significant changes (p > 0.05). These findings sug gest that RF exposure may contribute to the observed cytotoxic responses in CRC cells while exerting limited effects on non-malignant cells, suggesting a promising strategy for targeted therapy.
dc.description.sponsorshipThis study was financially supported by the Istanbul University Scientific Research Projects Coordination Unit (BAP), Project Nos. TDP-2020-36598 and TSA-2023-39461. Bu çalışma, İstanbul Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi (BAP) tarafından TDP-2020-36598 ve TSA-2023-39461 numaralı projelerle finansal olarak desteklenmiştir.
dc.identifier.citationErol Bozkurt, A., Süleymanoğlu, M., Cinek, T., Karali, N., Ballıkaya, S., İyikesici, M. S., & Kuruca, S. (2026). The effect of radiofrequency exposure on the cytotoxic activity of sunitinib and a novel sunitinib-class compound 4, in colorectal cancer cells. International Journal of Molecular Sciences, 27(13), pp. 1-16. https://doi.org/10.3390/ijms27135953
dc.identifier.doi10.3390/ijms27135953
dc.identifier.endpage16
dc.identifier.issn1422-0067
dc.identifier.issue13
dc.identifier.pmidPMID: 42450219
dc.identifier.scopus2-s2.0-105045016000
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3390/ijms27135953
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1574
dc.identifier.volume27
dc.identifier.wosWOS:001818583500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorCinek, Tuğçe
dc.institutionauthorid0000-0001-5625-0189
dc.language.isoen
dc.publisherMDPI Publishing
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColorectal Cancer
dc.subjectRadiofrequency Hyperthermia
dc.subjectCell Viability
dc.subjectTyrosine Kinase Inhibitor
dc.subject2-Indolinone
dc.subjectSunitinib
dc.titleThe effect of radiofrequency exposure on the cytotoxic activity of sunitinib and a novel sunitinib-class compound 4, in colorectal cancer cells
dc.typeArticle
dspace.entity.typePublication

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