Preparation and characterization studies of etodolac suppositories: investigation on oleaginous blends of Witepsol® H15

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorÜner, Burcu
dc.contributor.authorKaraküçük, Alptuğ
dc.date.accessioned2023-04-11T12:07:00Z
dc.date.available2023-04-11T12:07:00Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractEtodolac is a non-steroidal anti-inflammatory drug that is categorized as a BCS class-II drug due to its low aqueous solubility and high permeability. Frequent dosing, extensive liver metabolism, and low dissolution rates are major limitations of etodolac. The present study focuses on the designing of novel suppository base blends for providing an effective delivery of etodolac. The oils (Caprylic/capric triglyceride, isopropyl isostearate, and isopropyl palmitate) were added to Witepsol® H15 to form suppository base blends. White, odorless, and torpedo-shaped suppositories were developed by using two parts of Witepsol® H15 and one part of the oil. All of the suppositories prepared with different blends were found uniform in weight and content. The mechanical strength of all suppositories was in an acceptable range for suppositories (2.0 – 3.8 kg/cm2). The suppositories showed a disintegration time between 13 and 19 minutes. First-order release kinetics were observed after the in vitro release studies. The suppository base blends released 85%- 90% of etodolac in the first hour while 60% of etodolac was released from Witepsol® H15 base alone. Prolonged drug release was achieved after 2 hours all of the formulations reached the plateau levels. The oil blends exhibited higher release percentages (96% - 99%) than plain Witepsol® H15 base (89%). Therefore novel suppository base blends could be a promising formulation ingredient for the etodolac suppositories.en_US
dc.identifier.citationÖzdemir, S., Üner, B., & Karaküçük, A. (2023). Preparation and characterization studies of etodolac suppositories: investigation on oleaginous blends of Witepsol® H15. Journal of Research in Pharmacy, 27(2), 837-847. http://dx.doi.org/10.29228/jrp.364en_US
dc.identifier.doi10.29228/jrp.364en_US
dc.identifier.endpage847en_US
dc.identifier.issn2630-6344
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85151362370en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage837en_US
dc.identifier.trdizinid1177720
dc.identifier.urihttp://dx.doi.org/10.29228/jrp.364
dc.identifier.urihttps://hdl.handle.net/20.500.13055/443
dc.identifier.volume27en_US
dc.identifier.wosWOS:001121637400004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherMarmara University Pressen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSuppositoryen_US
dc.subjectEtodolacen_US
dc.subjectSuppository Baseen_US
dc.subjectOilen_US
dc.subjectWitepsol® H15en_US
dc.titlePreparation and characterization studies of etodolac suppositories: investigation on oleaginous blends of Witepsol® H15en_US
dc.typeArticleen_US
dspace.entity.typePublication

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