Protective effects of boric acid on HBV-transgenic mice with chronic alcohol consumption: An experimental study

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dc.authorid0000-0002-5871-1732
dc.authorid0000-0001-9446-4399
dc.authorid0000-0001-8250-8227
dc.authorid0000-0001-7243-3671
dc.authorid0000-0002-4815-5728
dc.authorid0000-0001-6032-3328
dc.authorid0000-0002-5757-1256
dc.authorid0000-0001-7724-6488
dc.contributor.authorErgüven, Pelin
dc.contributor.authorTanrıkulu Küçük, Sevda
dc.contributor.authorŞevgin, Kübra
dc.contributor.authorDeğirmencioğlu, Sevgin
dc.contributor.authorÇetinalp, Pınar
dc.contributor.authorAksu, Soner
dc.contributor.authorGün Atak, Palmet
dc.contributor.authorSöğüt, İbrahim
dc.date.accessioned2025-05-15T15:52:55Z
dc.date.available2025-05-15T15:52:55Z
dc.date.issued2025
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractThis study aimed to investigate the protective effect of boric acid supplementation against liver damage in chronic alcohol-dependent HBV transgenic mice. The HBV transgenic mice were divided into four groups: control (C), boric acid(B), alcohol(A), and alcohol + boric acid(A + B). Blood alcohol concentration (BAC), alanine aminotransferase (ALT), aspartate aminotransferase(AST), reactive oxygen species(ROS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total antioxidant capacity (TAS), total oxidant capacity (TOS) levels, and oxidative stress index (OSI) were examined biochemically. H&E, PAS, Masson trichrome, and TUNEL staining were performed. Caspase 3, cytochrome c, and APAF-1 expression levels were determined by qRT-PCR. The alcohol group exhibited significantly higher levels of ROS, MDA, TOS, OSI, and mRNA expressions of Cytochrome c, caspase 3, and APAF-1, while TAS level and CAT activity were significantly lower compared to the boric acid group. Compared to the control group, the alcohol group exhibited significantly increased TOS, OSI, AST levels, APAF-1 mRNA expression, and the number of TUNEL-positive cells, along with a reduction in GPx activity (p < 0.05). However, in the alcohol + boric acid group, TOS and AST levels were significantly higher compared to the control group (p < 0.05), and TOS was higher compared to the boric acid group (p < 0.01). Among the boron-treated groups, only the TOS level was lower in the boric acid group compared to the alcohol + boric acid group (p < 0.01). Histopathological examination revealed reduced sinusoidal dilatation and connective tissue distribution in the boric acid-supplemented groups. These findings suggest that boric acid supplementation may mitigate oxidative damage and histopathological alterations associated with chronic alcohol consumption in HBV-transgenic mice.
dc.description.sponsorshipThis study was supported by the Istanbul Bilim University TTO 02–066209 project. Bu çalışma, İstanbul Bilim Üniversitesi TTO 02–066209 projesi tarafından desteklenmiştir.
dc.identifier.citationErgüven, P., Tanrıkulu Küçük, S., Şevgin, K., Değirmencioğlu, S., Çetinalp, P., Aksu, S., Gün Atak, P., & Söğüt, İ. (2025). Protective effects of boric acid on HBV-transgenic mice with chronic alcohol consumption: An experimental study. Biochemical and Biophysical Research Communications, 768, pp. 1-8. https://doi.org/10.1016/j.bbrc.2025.151956
dc.identifier.doi10.1016/j.bbrc.2025.151956
dc.identifier.endpage8
dc.identifier.issn1090-2104
dc.identifier.issn0006-291X
dc.identifier.pmid40345014
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.bbrc.2025.151956
dc.identifier.urihttps://hdl.handle.net/20.500.13055/985
dc.identifier.volume768
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAksu, Soner
dc.institutionauthorid0000-0001-6032-3328
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlcoholic Hepatitis
dc.subjectApoptosis
dc.subjectBoric Acids
dc.subjectLiver
dc.subjectOxidative Stress
dc.titleProtective effects of boric acid on HBV-transgenic mice with chronic alcohol consumption: An experimental study
dc.typeArticle
dspace.entity.typePublication

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