Experimental sciatic nerve neuropathy caused by diclofenac sodium in rats

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dc.authorid0000-0002-7651-7132
dc.authorid0000-0003-4118-8129
dc.authorid0000-0003-4328-0690
dc.authorid0000-0002-3865-7206
dc.authorid0000-0001-7892-3129
dc.authorid0000-0002-1081-3545
dc.authorid0000-0002-5291-4483
dc.authorid0000-0001-6854-2197
dc.contributor.authorAykut, Ali Maksut
dc.contributor.authorKaya, Mustafa Emrah
dc.contributor.authorOral, Şükrü
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorAras, Mustafa
dc.contributor.authorYılmaz, Atilla
dc.contributor.authorÖzgür, Tümay
dc.contributor.authorDoğan, Serdar
dc.date.accessioned2026-08-21T18:02:12Z
dc.date.available2026-08-21T18:02:12Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Our aim in this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) values of diclofenac sodium, which is a non-steroidal anti-inflammatory analgesic, after sciatic nerve injury, to examine the histopathological changes in the sciatic nerve, and to examine the results and enable important changes in treatment. It is one of the rare studies conducted histopathologically on post-injection sciatic nerve damage of diclofenac sodium, and the parameters of our biochemical approach have not been evaluated before in the literature. METHODS: study was divided into 5 main groups as control, sham, trauma, isotonic fluid, and diclofenac sodium. Sham, trauma, isotonic fluid, and diclofenac sodium groups were divided into four subgroups as early stage (day 1, day 3) and late stage (day 7 and day 14). Subjects in each group were evaluated daily by neurological examination according to the Tarlov scale. In all groups except the control group, the sciatic nerve was exposed through appropriate surgical procedures. TAS, TOS, and OSI were run on blood samples biochemically. Nerve tissue samples were evaluated histopathologically and immunohistochemically. RESULTS: There was a significant difference in pairwise comparison of the groups in terms of CASPASE-3 values. A statis tically significant difference was found between the groups in terms of myelin thickness and axon diameter. A statistically significant difference was found between the groups in terms of nerve diameter values. CONCLUSION: Our study demonstrates that intramuscular injections of diclofenac sodium have potential harmful ef fects. We recommend that alternative methods of using diclofenac sodium intramuscularly be preferred whenever possi ble due to the potential complications associated with this drug, that healthcare professionals receive necessary training on intramuscular administration, that the procedures be performed more carefully, and that patients be informed about these complications.
dc.identifier.citationAykut, A. M., Kaya, M. E., Oral, Ş., Serarslan, Y., Aras, M., Yılmaz, A., Özgür, T., & Doğan, S. (2026). Experimental sciatic nerve neuropathy caused by diclofenac sodium in rats. Northern Clinics of Istanbul, 13(3), pp. 327-335. https://doi.org/10.14744/nci.2026.96337
dc.identifier.doi10.14744/nci.2026.96337
dc.identifier.endpage335
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue3
dc.identifier.pmidPMID: 42516788
dc.identifier.scopus2-s2.0-105045642231
dc.identifier.scopusqualityQ2
dc.identifier.startpage327
dc.identifier.urihttps://doi.org/10.14744/nci.2026.96337
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1599
dc.identifier.volume13
dc.identifier.wosWOS:001829001100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorYılmaz, Atilla
dc.institutionauthorid0000-0002-1081-3545
dc.language.isoen
dc.publisherKare Publishing
dc.relation.ispartofNorthern Clinics of Istanbul
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiclofenac Sodium
dc.subjectInjection
dc.subjectNeuropathy
dc.subjectSciatic
dc.titleExperimental sciatic nerve neuropathy caused by diclofenac sodium in rats
dc.typeArticle
dspace.entity.typePublication

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