Tannic acid and copper-modified ZIF-8 metal organic framework as a cefotaxime delivery system for antimicrobial activity

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dc.authorid0000-0001-6915-0283
dc.authorid0000-0002-5853-5150
dc.authorid0000-0001-9372-3168
dc.contributor.authorPirinççi Tok, Yağmur
dc.contributor.authorÖzsoy, Münteha
dc.contributor.authorDamar Çelik, Damla
dc.date.accessioned2026-04-20T06:46:16Z
dc.date.available2026-04-20T06:46:16Z
dc.date.issued2026
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.description.abstractObjectives: Antibiotic resistance has become a global public health threat. Cefotaxime (CTX), a third-generation cephalosporin, is approved for use in infants, children, and adults with various microbial infections, particularly those affecting the central nervous system. This study aimed to synthesize and characterize zeolitic imidazolate framework (ZIF)-8-based drug delivery systems (DDSs) to enhance antimicrobial activity and control CTX release. Materials and Methods: ZIF-8 was synthesized via the coordination network of Zn ions and 2-methylimidazole and subsequently modified with tannic acid (TA) and copper ions (Cu2+). ZIF-8 MOF and its derivatives were characterized by Fourier Transform Infrared, zeta potential, in vitro dissolution rate, and in vitro antimicrobial activity. Results: The drug loading capacity and encapsulation efficiency were found to be 39.50 ± 1.19% and 98.75 ± 2.96%, respectively, for ZIF-8@TA@CTX, and 40.75 ± 1.22% and 97.75 ± 2.93%, respectively, for ZIF-8@TA@Cu@CTX. Following 48 hours, the drug released from ZIF-8@TA@Cu@CTX was detected at 62.83 ± 1.89% at pH 5.0 and 83.19 ± 2.50% at pH 7.4 after 48 h, with dissolution profiles best fitting the Korsmeyer–Peppas model. The synthesized DDSs demonstrated a higher antibacterial activity against gram-positive bacteria than against gram-negative bacteria. Conclusion: ZIF-8 MOF DDs may serve as an alternative for delivering drugs to infected areas due to their controlled release under low pH conditions.
dc.identifier.citationPirinççi Tok, Y., Özsoy, M., & Damar Çelik, D. (2026). Tannic acid and copper-modified ZIF-8 metal organic framework as a cefotaxime delivery system for antimicrobial activity. Turkish Journal of Pharmaceutical Sciences, https://doi.org/10.4274/tjps.galenos.2026.80025
dc.identifier.doi10.4274/tjps.galenos.2026.80025
dc.identifier.issn2148-6247
dc.identifier.issn1304-530X
dc.identifier.pmidPMID: 41960755
dc.identifier.urihttps://doi.org/10.4274/tjps.galenos.2026.80025
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1433
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Index
dc.institutionauthorPirinççi Tok, Yağmur
dc.institutionauthorid0000-0001-6915-0283
dc.language.isoen
dc.publisherGalenos Publishing House
dc.relation.ispartofTurkish Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibiotic Resistance
dc.subjectMetal Organic Framework
dc.subjectZeolitic Imidazolate Frameworks
dc.subjectCefotaxime
dc.titleTannic acid and copper-modified ZIF-8 metal organic framework as a cefotaxime delivery system for antimicrobial activity
dc.typeArticle
dspace.entity.typePublication

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