Redox-responsive and mucoadhesive nanoparticles: An overlooked synergy in modern drug delivery

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dc.authorid0000-0003-2185-2619
dc.authorid0000-0002-9127-2380
dc.authorid0000-0002-3052-4556
dc.authorid0000-0003-2497-9359
dc.contributor.authorKüçükertuğrul Çelik, Sibel
dc.contributor.authorŞentürk, Sema
dc.contributor.authorBal, Kevser
dc.contributor.authorKaplan, Özlem
dc.contributor.authorGök, Mehmet Koray
dc.date.accessioned2026-02-09T14:40:44Z
dc.date.available2026-02-09T14:40:44Z
dc.date.issued2026
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümü
dc.description.abstractThe continuous advancement of therapeutic technologies has intensified the pursuit of drug delivery systems that respond intelligently to physiological and pathological stimuli, thereby enabling precise, localized, and sustained therapeutic outcomes. Among redox-based approaches, systems responsive to intracellular glutathione (GSH) have attracted particular attention due to their ability to trigger disulfide bond cleavage and controlled release within diseased tissues. Mucoadhesive systems, on the other hand, prolong residence time on mucosal surfaces through non-covalent interactions and covalent bond formation, thereby facilitating increased absorption and decreased clearance. Despite their individual successes, the integration of these two mechanisms remains underexplored. This review critically examines the coupling of redox sensitivity and mucoadhesion, highlighting how disulfide-based bonds can simultaneously function as both redox-cleavable and mucoadhesive moieties.
dc.identifier.citationKüçükertuğrul Çelik, S., Şentürk, S., Bal, K., Kaplan, Ö., & Gök, M. K. (2026). Redox-responsive and mucoadhesive nanoparticles: An overlooked synergy in modern drug delivery. European Polymer Journal, 243, pp. 1-28. https://doi.org/10.1016/j.eurpolymj.2025.114475
dc.identifier.doi10.1016/j.eurpolymj.2025.114475
dc.identifier.endpage28
dc.identifier.issn0014-3057
dc.identifier.issn1873-194
dc.identifier.scopus2-s2.0-105026129234
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2025.114475
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1301
dc.identifier.volume243
dc.identifier.wosWOS:001657709000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorŞentürk, Sema
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Polymer Journal
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRedox-Responsive Nanoparticles
dc.subjectMucoadhesive Systems
dc.subjectStimuli-Responsive Drug Delivery
dc.titleRedox-responsive and mucoadhesive nanoparticles: An overlooked synergy in modern drug delivery
dc.typeReview Article
dspace.entity.typePublication

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