Efficacy-oriented approach for medium-sized follicles: A perspective on stimulation, expectation, and triggering strategy in IVF cycles

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dc.authorid0000-0002-5638-3675
dc.authorid0000-0001-8892-3974
dc.authorid0000-0001-5695-2586
dc.authorid0000-0002-6799-5909
dc.authorid0000-0001-8859-0639
dc.authorid0000-0002-8121-7708
dc.authorid0000-0001-6940-7608
dc.authorid0000-0001-8426-8490
dc.contributor.authorAydın, Gerçek
dc.contributor.authorErgin, Elif
dc.contributor.authorAraç, Merve
dc.contributor.authorBülbül, Mehmet
dc.contributor.authorÇalışkan, Eray
dc.contributor.authorHatırnaz, Şafak
dc.contributor.authorDahan, Michael
dc.contributor.authorMalvasi, Antonio
dc.contributor.authorTinelli, Andrea
dc.date.accessioned2026-04-20T07:35:49Z
dc.date.available2026-04-20T07:35:49Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective: To assess the therapeutic significance of routinely aspirating mid-sized fol licles (14.0–16.9 mm) during oocyte pick-up (OPU) by looking at procedural efficiency and embryo usage in cycles with varied follicular cohorts. Methods: In vitro fertilization (IVF) cycles with follicles classified as large (≥17 mm) or mid-sized (14.0–16.9 mm) at the time of OPU were included in this prospective cohort. Each group's oocytes were extracted and treated independently while main taining rigorous traceability. Analysis was performed on embryologic results, opera tive time factors, and embryo transfer utilization across successive transfer attempts. Pregnancy outcomes and the length of the operation were investigated. Laboratory results pertaining to trigger strategies were assessed descriptively. Results: When measured per mature oocyte, oocytes from mid-sized follicles showed comparable fertilization and blastocyst development rates. However, only a small percentage of embryo transfers included embryos from mid-sized follicles, especially in the initial two transfer attempts. Large follicles had a longer total OPU duration, and cycles that resulted in miscarriage had significantly longer operative times among large-follicle-derived embryo transfers. For mid-sized follicles, there were no differ ences in the length of the procedure based on the pregnancy outcome. Conclusion: The contribution of mid-sized follicle-derived oocytes to embryo trans fer selection seems to be restricted in everyday practice, despite their reassuring laboratory competence. Procedural efficiency is a potentially significant factor in customized IVF care, as evidenced by the correlation between longer operating times and worse clinical outcomes. In certain clinical situations, a focused stimula tion and aspiration approach might be suitable without obviously jeopardizing cu mulative results.
dc.identifier.citationAydın, G., Ergin, E., Araç, M., Bülbül, M., Çalışkan, E., Hatırnaz, Ş., Dahan, M., Malvasi, A., & Tinelli, A. (2026). Efficacy-oriented approach for medium-sized follicles: A perspective on stimulation, expectation, and triggering strategy in IVF cycles. International Journal of Gynecology and Obstetrics, pp. 1-8. https://doi.org/10.1002/ijgo.71009
dc.identifier.doi10.1002/ijgo.71009
dc.identifier.endpage8
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.pmidPMID: 41949741
dc.identifier.scopus2-s2.0-105035169476
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/ijgo.71009
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1434
dc.identifier.wosWOS:001734758100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAydın, Gerçek
dc.institutionauthorid0000-0002-5638-3675
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Gynecology and Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAssisted Reproductive Technology
dc.subjectDuration
dc.subjectEfficiency
dc.subjectFertility
dc.subjectFollicle Size
dc.subjectIn Vitro Fertilization
dc.subjectOocyte Pick-Up
dc.titleEfficacy-oriented approach for medium-sized follicles: A perspective on stimulation, expectation, and triggering strategy in IVF cycles
dc.typeArticle
dspace.entity.typePublication

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