Phthalocyanines bearing silazane group for colorectal cancer

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dc.authorid0000-0002-7869-1281en_US
dc.authorscopusid57207301568en_US
dc.authorwosidAAV-2070-2021en_US
dc.contributor.authorÖzdemir, Mücahit
dc.contributor.authorArtuç, Gamze Özgül
dc.contributor.authorGuler, Eray Metin
dc.contributor.authorYalçın, Bahattin
dc.contributor.authorSalan, Ümit
dc.contributor.authorBozali, Kübra
dc.contributor.authorGörgülü, Ahmet Orhan
dc.contributor.authorBulut, Mustafa
dc.date.accessioned2021-12-06T09:31:03Z
dc.date.available2021-12-06T09:31:03Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.description.abstractThe synthesis of bis(trimethylsilyl)amine substituted zinc(II), and indium(III) chloride phthalocyanine complexes have been performed. The obtained compounds were characterized by spectroscopic methods. All synthesized phthalocyanine derivatives were evaluated for cytotoxic, genotoxic, and apoptotic activities on LoVo cell lines which are the standard colorectal cancer cell lines derived from metastatic site: left supraclavicular region. Nonperipheral silazane substituted zinc phthalocyanine (5) showed quite different behavior from all the other compounds analyzed and found to be the best cytotoxic, genotoxic, and apoptotic compound. All derivatives showed no proliferative effect at all doses. All phthalocyanine compounds increased cytotoxicity, DNA damage, apoptosis, and intracellular ROS dose-dependent manner. To explain and verify in vitro tests, phthalocyanine compound structures were optimized using density functional theory, and in silico molecular docking studies on B-DNA dodecamer were performed. Both the experimental and theoretical findings comply with each other.en_US
dc.identifier.citationOzdemir, M., Artuc, G. O., Guler, E. M., Yalcin, B., Salan, U., Bozali, K., Gorgulu, A. O., & Bulut, M. (Dec 2021). Phthalocyanines bearing silazane group for colorectal cancer. Dyes and Pigments, 196, pp. 1-12. 109832. https://doi.org/10.1016/j.dyepig.2021.109832en_US
dc.identifier.doi10.1016/j.dyepig.2021.109832en_US
dc.identifier.endpage12en_US
dc.identifier.scopus2-s2.0-85115921953en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.dyepig.2021.109832
dc.identifier.urihttps://hdl.handle.net/20.500.13055/68
dc.identifier.volume196en_US
dc.identifier.wosWOS:000702870500003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorArtuç, Gamze Özgül
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofDyes and Pigmentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilazane phthalocyanineen_US
dc.subjectPharmacokineticen_US
dc.subjectLoVo cellen_US
dc.subjectColorectal canceren_US
dc.subjectDNA bindingen_US
dc.titlePhthalocyanines bearing silazane group for colorectal canceren_US
dc.typeArticleen_US
dspace.entity.typePublication

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