The therapeutic approach to fibrocystic breast disease in the MCF-10A cell culture model: Striking efficacy of polyphenol

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dc.authorid0000-0002-3635-8421en_US
dc.authorscopusid57194783843en_US
dc.authorwosidDVP-7029-2022en_US
dc.contributor.authorÇelik, İncilay
dc.contributor.authorSeyhan, Mehmet Fatih
dc.contributor.authorCeviz, Ayşe Begüm
dc.contributor.authorAydoğan, Çağatay
dc.contributor.authorYılmaz Aydoğan, Hülya
dc.contributor.authorÖztürk, Oğuz
dc.date.accessioned2024-06-13T10:33:05Z
dc.date.available2024-06-13T10:33:05Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalıen_US
dc.description.abstractBackground and Aims: Standard treatment regimens for fibrocystic breast disease (FBD) do not provide a permanent cure and have undesirable side effects. This study aims to investigate the therapeutic potential of different honey and propolis, as well as some important polyphenols, on breast epithelial cells (MCF-10A). Materials and Methods: The effects of five honey, two propolis extracts and seven polyphenol samples on the cell viability were assessed the WST-1 assay. Content analysis of the propolis samples was performed using high performance liquid chromatography (HPLC). Results: Chestnut and cedar honey had antiproliferative effects on MCF-10A cells at all doses (1-10 μg/mL), as well as pine honey at the highest dose. However, multifloral honey had no similar effect. Chinese propolis had significant antiproliferative effects on MCF-10A cells at doses of 50-250 μg/mL and on the human periodontal ligament (hPDL) control cells at a dose of 5 μg/mL. Türkiye propolis only had an antiproliferative effect on MCF-10A cells at the highest dose (p = 0.0013). Higher levels of ferulic acid, kaempferol, caffeic acid, pinocembrin and quercetin were detected in Türkiye propolis, while Chinese propolis was rich in pinostrobin. Ferulic acid, pinostrobin and galangin showed antiproliferative properties on MCF-10A cells (p < 0.0001), whereas the remaining four polyphenols had no significant effect on cell viability (p > 0.05). Conclusion: The findings of the study highlight the antiproliferative effects of pinostrobin, ferulic acid and galangin on MCF-10A cells and has also confirmed the antiproliferative effects of honey and propolis samples to be due to their polyphenolic properties. Therefore, this study suggests that polyphenolic substances may have both preventive and therapeutic potential in FBD.en_US
dc.identifier.citationÇelik, İ., Seyhan, M. F., Ceviz, A. B., Aydoğan, Ç., Yılmaz Aydoğan, H., & Öztürk, O. (2024). The therapeutic approach to fibrocystic breast disease in the MCF-10A cell culture model: Striking efficacy of polyphenol. Istanbul Journal of Pharmacy, 54(1), pp. 40–48. https://doi.org/10.26650/IstanbulJPharm.2024.1299245en_US
dc.identifier.doi10.26650/IstanbulJPharm.2024.1299245en_US
dc.identifier.endpage48en_US
dc.identifier.issn2587-2087
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.trdizinid1279962
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2024.1299245
dc.identifier.urihttps://hdl.handle.net/20.500.13055/721
dc.identifier.volume54en_US
dc.identifier.wosWOS:001216536800007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorCeviz, Ayşe Begüm
dc.language.isoenen_US
dc.publisherIstanbul Universityen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibrocystic Breasten_US
dc.subjectHoneyen_US
dc.subjectMCF-10Aen_US
dc.subjectPolyphenolen_US
dc.subjectPropolisen_US
dc.titleThe therapeutic approach to fibrocystic breast disease in the MCF-10A cell culture model: Striking efficacy of polyphenolen_US
dc.typeArticleen_US
dspace.entity.typePublication

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