Trends and regional differences for fertil ity preservation procedures in women with breast cancer

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dc.authorid0000-0003-2287-799X
dc.contributor.authorTuran, Volkan
dc.contributor.authorBedoschi, Giuliano
dc.contributor.authorLee, Dong-Yun
dc.contributor.authorBarbosa, Caio Parente
dc.contributor.authorOliveira, Renato de
dc.contributor.authorSaçıntı, Koray Görkem
dc.contributor.authorSönmezer, Murat
dc.contributor.authorLambertini, Matteo
dc.contributor.authorMassarotti, Claudia
dc.contributor.authorSchaub, Amelia
dc.contributor.authorWang, Erica
dc.contributor.authorGayete-Lafuente, Sonia
dc.contributor.authorDunlop, Cheryl
dc.contributor.authorAnderson, Richard A.
dc.contributor.authorBang, Heejung
dc.contributor.authorOktay, Kutluk H.
dc.date.accessioned2024-10-03T05:32:52Z
dc.date.available2024-10-03T05:32:52Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractIntroduction : Breast cancer is the most common malignancy in women of reproductive age and chemotherapy protocols impair fertility, frequently necessitating fertility preservation (FP) referral. Embryo, oocyte, or ovarian tissue cryopreservation are established FP modalities in women with breast cancer but there are few data on their uptake over time. In this study our aim was to determine the regional time trends and utility differences for fertility preservation methods of reproductive tissue cryopreservation. Methods : This multicenter study included 1,623 women diagnosed with breast cancer from seven tertiary centers in six countries (Brazil, Italy, Scotland, South Korea, Turkey, USA). Participant centers provided the details of FP cryopreservation approaches broken down annually from 2012 to 2021. Women with newly diagnosed breast cancer, aged 18-45 years who were referred for FP at participating centers and had normal ovarian function at the time were included. Results : We found a mean increase of 7% per year (p=0.002, adjusting for centers) in the number of women referred for FP. Of those who were referred (n=1623), a mean 38.7% underwent FP (n=629), with a range of 12% in South Korea) to 95% in Brazil. The number of women undergoing ovarian stimulation for FP continually increased until 2021, with oocyte cryopreservation being the most common procedure throughout the study period (p=0.014 for time trend). The proportion of random start ovarian stimulation cycles increased each year from 58.3% in 2012 to 86.8% in 2021, (p=0.005 for time trend, and p=0.04 for 2012 vs. 2021). Conclusions : The utility of FP has steadily increased for young women with breast cancer over the last decade, although regional differences significantly influence FP practices. The findings of our study could have value for policy making in FP care for young women with breast cancer at the local, regional, or global level. Micro abstract Breast cancer is the most common malignancy in women of reproductive age and chemotherapy protocols impair fertility, frequently necessitating fertility preservation referral. The utility of fertility preservation has steadily increased for young women with breast cancer over the last decade, although regional differences significantly influence fertility preservation practices.
dc.identifier.citationTuran, V., Bedoschi, G., Lee, D.-Y., Barbosa, C. P., Oliveira, R., Saçıntı, K. G., Sönmezer, M., Lambertini, M., Massarotti C., Schaub, A., Wang, E., Gayete-Lafuente, S., Dunlop, C., Anderson, R. A., Bang, H., Oktay, Kutluk H. (2024). Trends and regional differences for fertil ity preservation procedures in women with breast cancer. Clinical Breast Cancer. https://doi.org/10.1016/j.clbc.2024.09.011
dc.identifier.doi10.1016/j.clbc.2024.09.011
dc.identifier.issn1938-0666
dc.identifier.issn1526-8209
dc.identifier.pmidPMID: 39428290
dc.identifier.scopus2-s2.0-85205318422
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.clbc.2024.09.011
dc.identifier.urihttps://hdl.handle.net/20.500.13055/815
dc.identifier.wosWOS:001324635100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTuran, Volkan
dc.institutionauthorid0000-0003-2287-799X
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical Breast Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Cancer
dc.subjectCryopreservation
dc.subjectEmbryo
dc.subjectFertility Preservation
dc.subjectLetrozole
dc.subjectOocyte
dc.subjectOvarian Stimulation
dc.titleTrends and regional differences for fertil ity preservation procedures in women with breast cancer
dc.typeArticle
dspace.entity.typePublication

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