The role of Adenovirus-36 in adults with obesity-induced type 2 diabetes

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dc.authorid0000-0002-7855-7779en_US
dc.authorscopusid57643484200en_US
dc.contributor.authorTokman, Halit
dc.contributor.authorErgin, Sevgi
dc.contributor.authorSarıbaş, Suat
dc.contributor.authorDinç, Harika Öykü
dc.contributor.authorCengiz, Mahir
dc.contributor.authorYavuzer, Serap
dc.contributor.authorÇizmecigil, Utku Yusuf
dc.contributor.authorÖnder, Nuri T.
dc.contributor.authorYılmaz, Hüseyin
dc.contributor.authorEryiğit, Önder Yüksel
dc.contributor.authorGareayaghi, Nesrin
dc.contributor.authorKocazeybek, Bekir Sami
dc.date.accessioned2022-12-16T14:32:08Z
dc.date.available2022-12-16T14:32:08Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programıen_US
dc.description.abstractBackground: Obesity may also develop due to a viral infection caused by adenovirus 36. We aimed to detect the presence of neutralizing antibodies against Ad-36 in adult patients who developed type 2 diabetes due to obesity (BMI ≥ 30 kg/m2). Methods: The patient group (PG) was composed of 80 obese people with type 2 diabetes, the patient control group (PCG) was composed of 40 non-obese people with type 2 diabetes, and the healthy control group (HCG) was composed of 40 non-obese people without type 1 or type 2 diabetes in this case-control study. The presence of Ad-36 neutralizing antibodies was studied by serum neutralization assay. Results: A significant difference was found between the PG and HCG in terms of Ad-36 antibody positivity (p < 0.0001) but no significant difference was detected between the PG and the PCG (p > 0.05). BMI, serum leptin, adiponectin, and triglyceride levels were significantly higher in the PG (p < 0.05). Conversely, TNF-α and IL-6 levels were significantly lower in the PG (p < 0.0001). When the two groups were compared, the mean levels of total cholesterol and LDL in the PG were found to be high, although not significant (p > 0.05). In type 2 diabetes patients (n = 120), age, BMI, HDL, LDL, triglyceride, total cholesterol, Ad-36 presence, leptin, adiponectin, TNF-α, and IL-6 parameters were taken as independent variables for logistic regression. While BMIs was found to be significant (odds ration [OR] = 2.358; p = 0.0001, 95% Cl 1.507 - 3.690, Ad-36 presence was found to be a significant (OR = 27.352; p = 0.003, 95% Cl 3.157 - 236.961). Our study showed that BMI and Ad-36 increase type 2 diabetes risk by 2.3 and 27.3-fold in the PG and PCG (type 2 diabetes patients) versus the HCG. There was also a significant difference between PCG and HCG. Conclusions: We suggest that Ad-36 seropositivity is also a risk factor for the development of type 2 diabetes independent of being obese. © 2022 Verlag Klinisches Labor GmbH. All rights reserved.en_US
dc.identifier.citationTokman, H., Ergin, S., Sarıbaş, S., Dinç, H. Ö., Cengiz, M., Yavuzer, S., Çizmecigil, U. Y., Önder, N. T., Yılmaz, H., Eryiğit, Ö. Y., Gareayaghi, N. & Kocazeybek, B. S. (2022). The role of Adenovirus-36 in adults with obesity-induced type 2 diabetes. Clinical Laboratory, 68(11), 2348-2355. https://dx.doi.org/10.7754/Clin.Lab.2022.220226en_US
dc.identifier.doi10.7754/Clin.Lab.2022.220226en_US
dc.identifier.endpage2355en_US
dc.identifier.issn1433-6510
dc.identifier.issue11en_US
dc.identifier.pmidPMID: 36377995en_US
dc.identifier.scopus2-s2.0-85142193136en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2348en_US
dc.identifier.urihttps://dx.doi.org/10.7754/Clin.Lab.2022.220226
dc.identifier.urihttps://hdl.handle.net/20.500.13055/333
dc.identifier.volume68en_US
dc.identifier.wosWOS:000898559600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorEryiğit, Önder Yüksel
dc.language.isoenen_US
dc.publisherVerlag Klinisches Labor GmbHen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAd-36en_US
dc.subjectAdiponectinen_US
dc.subjectLeptinen_US
dc.subjectObesityen_US
dc.subjectType 2 Diabetesen_US
dc.titleThe role of Adenovirus-36 in adults with obesity-induced type 2 diabetesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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