A new approach to oral dosage forms: carrageenan-based vegan gummies
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Although the oral route is a common drug administration route, it still causes some patient compliance problems. Gummies are chewable gels that are commonly manufactured as dietary supplement carriers and their pharmaceutical use is still limited. Dexketoprofen trometamol is an anti-inflammatory and antipyretic drug. In the present study, dexketoprofen containing gummies were manufactured using carrageenan (Gelcarin®GP-379) as the gel-forming polymer. Potassium dihydrogen phosphate (KH2PO4) was used as the gelling agent in the research. The obtained gummies were characterized. For this purpose, gel viscosity measurements, morphological and physical characterizations, thermal analysis, and in vitro drug release studies were carried out. The viscosity of the gel mixtures was measured at 50°C, which was the pouring temperature of the gels into molds. The formulation containing the highest carrageenan and KH2PO4 had the highest viscosity. The physical characterization results showed that the gummy formulations could be prepared in a reproducible manner. The DSC thermograms showed that the melting peak of DXT was not observed in the gummy formulation. The in vitro dissolution test results of the gummies showed that decreasing the carrageenan and KH2PO4 concentration in gummy formulation accelerated the drug release. The obtained gummies exhibited an extended-release of up to 2 hours.
Açıklama
Anahtar Kelimeler
Vegan Drug Gummy, Dexketoprofen, Carrageenan, Oral Drug Gummy, Chewable Hydrogel
Kaynak
Journal of Research in Pharmacy
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
28
Sayı
1
Künye
Gültekin, H. E., İlhan, M., & Nalbantoğlu, F. (2024). A new approach to oral dosage forms: carrageenan-based
vegan gummies. Journal of Research in Pharmacy, 28(1), pp. 225-235. http://dx.doi.org/10.29228/jrp.690
