A new approach to oral dosage forms: carrageenan-based vegan gummies

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dc.authorscopusid58900040200en_US
dc.contributor.authorGültekin, Hazal Ezgi
dc.contributor.authorİlhan, Miray
dc.contributor.authorNalbantoğlu, Fırat
dc.date.accessioned2024-02-22T06:03:09Z
dc.date.available2024-02-22T06:03:09Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.description.abstractAlthough the oral route is a common drug administration route, it still causes some patient compliance problems. Gummies are chewable gels that are commonly manufactured as dietary supplement carriers and their pharmaceutical use is still limited. Dexketoprofen trometamol is an anti-inflammatory and antipyretic drug. In the present study, dexketoprofen containing gummies were manufactured using carrageenan (Gelcarin®GP-379) as the gel-forming polymer. Potassium dihydrogen phosphate (KH2PO4) was used as the gelling agent in the research. The obtained gummies were characterized. For this purpose, gel viscosity measurements, morphological and physical characterizations, thermal analysis, and in vitro drug release studies were carried out. The viscosity of the gel mixtures was measured at 50°C, which was the pouring temperature of the gels into molds. The formulation containing the highest carrageenan and KH2PO4 had the highest viscosity. The physical characterization results showed that the gummy formulations could be prepared in a reproducible manner. The DSC thermograms showed that the melting peak of DXT was not observed in the gummy formulation. The in vitro dissolution test results of the gummies showed that decreasing the carrageenan and KH2PO4 concentration in gummy formulation accelerated the drug release. The obtained gummies exhibited an extended-release of up to 2 hours.en_US
dc.identifier.citationGültekin, H. E., İlhan, M., & Nalbantoğlu, F. (2024). A new approach to oral dosage forms: carrageenan-based vegan gummies. Journal of Research in Pharmacy, 28(1), pp. 225-235. http://dx.doi.org/10.29228/jrp.690en_US
dc.identifier.doi10.29228/jrp.690en_US
dc.identifier.endpage235en_US
dc.identifier.issn2630-6344
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85185663647en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage225en_US
dc.identifier.urihttp://dx.doi.org/10.29228/jrp.690
dc.identifier.urihttps://hdl.handle.net/20.500.13055/655
dc.identifier.volume28en_US
dc.identifier.wosWOS:001167297700028en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherESCI - Emerging Sources Citation Indexen_US
dc.institutionauthorNalbantoğlu, Fırat
dc.language.isoenen_US
dc.publisherMarmara University Pressen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVegan Drug Gummyen_US
dc.subjectDexketoprofenen_US
dc.subjectCarrageenanen_US
dc.subjectOral Drug Gummyen_US
dc.subjectChewable Hydrogelen_US
dc.titleA new approach to oral dosage forms: carrageenan-based vegan gummiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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