Prolonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit model

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dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorÜner, Burcu
dc.date.accessioned2024-06-04T06:37:30Z
dc.date.available2024-06-04T06:37:30Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractLoteprednol etabonate (LE) is a topical corticosteroid for the symptomatic management of ocular conditions, encompassing both allergic and infectious etiologies. Owing to the dynamic and static barriers of the eye, LE exhibits signifcantly low bioavailability, necessitating an increase in the frequency of drug administration. The objective of this study is to overcome the limitations by developing niosomal systems loaded with LE. Design of Experiments (DoE) approach was used for the development of optimal niosome formulation. The optimal formulation was characterized using DLS, FT-IR, and DSC analysis. In vitro and ex vivo release studies were performed to demonstrate drug release patterns. After that HET-CAM evaluation was conducted to determine safety profle. Then, in vivo studies were carried out to determine therapeutic activity of niosomes. Zeta potential (ZP), particle size, polydispersity index (PI), and encapsulation efcacy (EE) were -33.8 mV, 89.22 nm, 0.192, and 89.6%, respectively. Medicated niosomes had a broad distribution within rabbit eye tissues and was absorbed by the aqueous humor of the bovine eye for up to 6 h after treatment. Cumulative permeated drug in the bovine eye and rabbit eye were recorded 52.45% and 54.8%, respectively. No irritation or hemorrhagic situation was observed accord ing to the results of HET-CAM study. Thus, novel LE-loaded niosomal formulations could be considered as a promising treatment option for the dry-eye-disease (DED) due to enhanced bioavailability and decreased side efects.en_US
dc.description.sponsorshipWashington University Anesthesiology and Pharmacology Research Center Lab -- 04-2523en_US
dc.identifier.citationÖzdemir, S. & Üner, B. (2024). Prolonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit model. AAPS PharmSciTech, 25(5), pp. 1-14. https://doi.org/10.1208/s12249-024-02838-2en_US
dc.identifier.doi10.1208/s12249-024-02838-2en_US
dc.identifier.endpage14en_US
dc.identifier.issn1530-9932
dc.identifier.issue5en_US
dc.identifier.pmidPMID: 38816667en_US
dc.identifier.scopus2-s2.0-85194994058en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-024-02838-2
dc.identifier.urihttps://hdl.handle.net/20.500.13055/713
dc.identifier.volume25en_US
dc.identifier.wosWOS:001237811300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAAPS PharmSciTechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesign of Experimentsen_US
dc.subjectDry Eye Disease Modelen_US
dc.subjectLoteprednol Etobonateen_US
dc.subjectNoisomeen_US
dc.subjectOcular Deliveryen_US
dc.titleProlonged release niosomes for ocular delivery of loteprednol: Ocular distribution assessment on dry eye disease induced rabbit modelen_US
dc.typeArticleen_US
dspace.entity.typePublication

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