CXCR1 gene SNP variability that affects mastitis resistance in Holstein cows in Türkiye

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dc.authorid0000-0001-9886-7515
dc.authorid0000-0003-0223-4444
dc.authorid0000-0002-4154-7104
dc.authorid0000-0001-5248-448X
dc.authorid0000-0001-6458-5747
dc.authorid0000-0001-7062-1521
dc.authorid0000-0003-1151-179X
dc.authorid0000-0002-0091-5812
dc.contributor.authorAvanus, Kozet
dc.contributor.authorYılmaz, Alper
dc.contributor.authorGüneş, Halil
dc.contributor.authorAltınel, Ahmet
dc.contributor.authorEkiz, Bülent
dc.contributor.authorYalçıntan, Hülya
dc.contributor.authorKeçici, Dilara
dc.contributor.authorDoğan, Nurşen
dc.date.accessioned2024-12-31T06:01:51Z
dc.date.available2024-12-31T06:01:51Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractGenotyping 16 SNPs of C-X-C motif chemokine receptor 1 (CXCR1) gene region which affects host resistance against mastitis disease was carried out in Holstein cows raised in Türkiye. In this study, the frequency of the undesirable C allele in the CXCR1 c.771C>G polymorphic region, associated with an incomplete response, was found to be high. Additionally, the genotypes c.1016AA and c.1016GG, which contribute to mastitis resistance, were observed at low frequencies. Several SNP loci in the CXCR1 gene, including c.606G>A, c.678G>A, c.1104G>A, c.1119+6C, c.1119+7A, and c.1119+10, significantly deviated from Hardy-Weinberg equilibrium (HWE) (P<0.0001), indicating violations of HWE assumptions such as random mating and absence of selection. The deviations at c.606G>A, c.678G>A, and c.1104G>A suggest strong selection pressures, likely due to artificial selection in Holstein cattle. These variants are synonymous mutations that do not alter the amino acid sequence but may influence protein synthesis through effects on mRNA stability, splicing, or translation efficiency. Furthermore, the absence of heterozygotes at loci c.1119+6C, c.1119+7A, and c.1119+10, which are located on untranslated regions (UTRs), potentially affecting gene expression by regulating mRNA stability, localization, or translation initiation, points to genetic drift or population substructure. These findings are important for understanding genetic variability and can inform marker-assisted selection programs to enhance breeding strategies while preserving genetic diversity for traits like disease resistance and milk production.
dc.description.sponsorshipThis study was supported by the Manning Foundation under the research and development project (KAP-2018-25), signed between the Istanbul University Rectorate’s Technology Transfer Application and Research Center Directorate and the Manning Foundation.
dc.identifier.citationAvanus, K., Yılmaz, A., Güneş, H., Altınel, A., Ekiz, B., Yalçıntan, H., Keçici, D., & Doğan N. (2025). CXCR1 Gene SNP variability that affects mastitis resistance in Holstein cows in Türkiye. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 31(1), pp. 119-124. https://doi.org/10.9775/kvfd.2024.32948
dc.identifier.doi10.9775/kvfd.2024.32948
dc.identifier.endpage124
dc.identifier.issn1309-2251
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.9775/kvfd.2024.32948
dc.identifier.urihttps://hdl.handle.net/20.500.13055/876
dc.identifier.volume31
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorAltınel, Ahmet
dc.institutionauthorid0000-0001-5248-448X
dc.language.isoen
dc.publisherKafkas Üniversitesi
dc.relation.ispartofKafkas Üniversitesi Veteriner Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCattle
dc.subjectPCR
dc.subjectSNP
dc.subjectMastitis
dc.subjectResistance
dc.titleCXCR1 gene SNP variability that affects mastitis resistance in Holstein cows in Türkiye
dc.typeArticle
dspace.entity.typePublication

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