Safety and effectiveness of controlled ovarian stimulation and oocyte retrieval during prepubertal and peripubertal period

Basit Öğe Kaydı
dc.authorid0000-0002-5363-474X
dc.authorid0000-0001-7090-5057
dc.authorid0000-0003-0815-3522
dc.authorid0000-0003-0121-3756
dc.authorid0000-0002-9557-3631
dc.authorid0000-0002-8873-0299
dc.authorid0000-0003-0264-0709
dc.authorid0000-0002-4504-669X
dc.authorid0000-0003-2287-799X
dc.authorid0000-0001-6101-1414
dc.contributor.authorSönmezer, Meltem
dc.contributor.authorGemici, Ali
dc.contributor.authorŞükür, Yavuz Emre
dc.contributor.authorTuran, Hande
dc.contributor.authorAlimoğulları, Ebru
dc.contributor.authorAvşar, Betül
dc.contributor.authorAtabekoğlu, Cem Somer
dc.contributor.authorÖzmen, Batuhan
dc.contributor.authorTuran, Volkan
dc.contributor.authorSönmezer, Murat
dc.date.accessioned2024-09-23T08:15:45Z
dc.date.available2024-09-23T08:15:45Z
dc.date.issued2024
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractPurpose Is it safe and efective to perform controlled ovarian stimulation (COS) and oocyte retrieval (OR) in prepubertal and peripubertal patients? Methods In this retrospective cohort study, data of 20 pre-/peripubertal patients who underwent COS and OR for the purpose of oocyte cryopreservation (OC) between 2008 and 2023 were reviewed. Following COS, all OR procedures were performed transabdominally using a vaginal ultrasound probe. Ovarian reserve was assessed by serum FSH, LH, estradiol, AMH, and antral follicle counts (AFC) in all subjects. All mature oocytes were vitrifed. Results Mean age of the patients was 15.05±1.87, mean AMH was 0.84±0.8 ng/ml, mean FSH was 6.39±3.95 IU/L, mean estradiol was 61.6±51.9 pg/ml, mean LH was 4.69±3.46 IU/L, and mean AFC was 5.5±5.82. Among the patients, 12 had regular menstrual cycle, 5 had irregular menstrual cycle, whereas 3 patients still did not have their menarche yet. The indi cations for OC were as follows: primary ovarian insufciency (n=7), ovarian surgery for ovarian tumors (n=5) or ovarian torsion (n=1), mosaic Turner syndrome (n=2), acute lymphoblastic leukemia (n=1) anaplastic B-cell lymphoma (n=1), Ewing’s sarcoma (n=1), Noonan syndrome (n=1), and Thalassemia (n=1). The mean number of oocytes retrieved, MII oocytes frozen, and maturation rate were 5.11±5.0, 3.92±4.48, and 75.1±25.6%, respectively. Stepwise linear regression analysis demonstrated a positive correlation between AFC and number of total oocytes retrieved and number of MII oocytes. In the case diagnosed with Noonan syndrome, all 7 retrieved oocytes were MI and all frozen at MI phase. No patient had any complication related to COS or OR. Conclusion Even though number of the enrolled subjects is limited and mean AMH is lower in our cohort, we demonstrated that performing COS and OR is safe in pre-/peripubertal patients. If required, transabdominal route can be performed in this age group for OR. AFC appears as a prognostic factor for stimulation outcome in this age group. Pediatric patients or young adolescents at risk for primary ovarian insufciency should not be discouraged from utilizing OC.
dc.identifier.citationMeltem, S., Ali, G., Emre, Ş. Y., Turan, H., Alimoğulları, E., Avşar, B., Atabekoğlu, C. S., Özmen B., Turan V., & Sönmezer, M. (2024).Safety and effectiveness of controlled ovarian stimulation and oocyte retrieval during prepubertal and peripubertal period. Journal of Assisted Reproduction and Genetics, 41(10), pp. 2823-2830. https://doi.org/10.1007/s10815-024-03262-y
dc.identifier.doi10.1007/s10815-024-03262-y
dc.identifier.endpage2830
dc.identifier.issn1573-7330
dc.identifier.issn1058-0468
dc.identifier.issue10
dc.identifier.pmidPMID: 39297990
dc.identifier.scopus2-s2.0-85204420837
dc.identifier.scopusqualityQ1
dc.identifier.startpage2823
dc.identifier.urihttps://doi.org/10.1007/s10815-024-03262-y
dc.identifier.urihttps://hdl.handle.net/20.500.13055/795
dc.identifier.volume41
dc.identifier.wosWOS:001316750000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTuran, Volkan
dc.institutionauthorid0000-0003-2287-799X
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Assisted Reproduction and Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOvarian Stimulation
dc.subjectPrimary Ovarian İnsufciency
dc.subjectPeripubertal Period
dc.subjectPrepubertal Period
dc.subjectTransabdominal Oocyte Retrieval
dc.titleSafety and effectiveness of controlled ovarian stimulation and oocyte retrieval during prepubertal and peripubertal period
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Tam Metin / Full Text
Boyut:
685.53 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu