Long-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females

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dc.authorid0000-0003-2282-2606
dc.authorid0000-0002-1874-7570
dc.authorid0000-0002-6732-8823
dc.authorid0000-0003-0121-3756
dc.authorid0000-0001-7479-7444
dc.authorid0000-0003-2287-799X
dc.authorid0000-0003-4851-8637
dc.authorid0000-0003-4102-6402
dc.authorid0000-0001-7397-2837
dc.contributor.authorKarakaş, Hasan
dc.contributor.authorTarçın, Gürkan
dc.contributor.authorBayramoğlu, Elvan
dc.contributor.authorTuran, Hande
dc.contributor.authorOcak, Süheyla
dc.contributor.authorTuran, Volkan
dc.contributor.authorEvliyaoğlu, Olcay
dc.contributor.authorTiraje, Tiraje
dc.contributor.authorApak, Hilmi
dc.contributor.authorErcan, Oya
dc.date.accessioned2026-02-10T08:50:26Z
dc.date.available2026-02-10T08:50:26Z
dc.date.issued2026
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractThis study aims to explore the long-term endocrine and gonadal effects of chemotherapy and radiotherapy in female acute lymphoblastic leukemia (ALL) patients. A cohort study included girls diagnosed with ALL and treated between 2000 and 2020. Patients with at least 2 years elapsed since treatment completion were included. Endocrinological evalua tions included anthropometric measures and pubertal status, as well as fasting insulin, glucose, lipid levels, and hormone assessments for adrenal, and thyroid functions. Reproductive functions were evaluated based on gonadotropin, estradiol, and anti-Müllerian hormone (AMH) levels. A total of 51 female patients were included. At the time of study participa tion, the mean age was 14.7 years, and the mean time since treatment completion was 9.4 years. At least one endocrine disorder was present in 39.2% of participants, with dyslipidemia, insulin resistance, and obesity being the most common. Low AMH levels (<1.1 ng/dL) were found in 41.6%, particularly in those who underwent bone marrow transplantation. A significant positive correlation was found between the time elapsed since treatment and AMH levels (p<0.001, r=0.612), while age at diagnosis, risk group (standard, intermediate or high risk), and cranial radiotherapy showed no significant associations. A substantial proportion of ALL survivors developed endocrine complications, with ovarian reserve compro mised in over 40% of cases. Notably, this is the first cohort study to demonstrate a significant positive correlation between AMH levels and the time elapsed since treatment, suggesting a potential for gonadal recovery except in those exposed to intensive chemotherapy or transplantation.
dc.description.sponsorshipOpen access funding provided by the Scientific and Tech nological Research Council of Türkiye (TÜBİTAK). Bu çalışma, Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK) tarafından sağlanan açık erişim fonuyla desteklenmiştir. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Bu araştırma, kamu, ticari veya kar amacı gütmeyen sektörlerdeki herhangi bir fon kuruluşundan özel bir hibe almamıştır.
dc.identifier.citationKarakaş, H., Tarçın, G., Bayramoğlu, E., Turan, H., Ocak, S., Turan, V., Evliyaoğlu, O., Tiraje, T., Apak, H., & Ercan, O. (2026). Long-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females. Annals of Hematology, 105(1), pp. 1-7. https://doi.org/10.1007/s00277-026-06783-x
dc.identifier.doi10.1007/s00277-026-06783-x
dc.identifier.endpage7
dc.identifier.issn1432-0584
dc.identifier.issue1
dc.identifier.pmidPMID: 41530579
dc.identifier.scopus2-s2.0-105027347819
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1007/s00277-026-06783-x
dc.identifier.urihttps://hdl.handle.net/20.500.13055/1310
dc.identifier.volume105
dc.identifier.wosWOS:001662885900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expanded
dc.institutionauthorTuran, Volkan
dc.institutionauthorid0000-0003-2287-799X
dc.language.isoen
dc.publisherSpringer Nature Link
dc.relation.ispartofAnnals of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectAnti-Müllerian Hormone
dc.subjectEndocrine Disorders
dc.subjectFertility
dc.subjectGonadal Toxicity
dc.subjectPreservation
dc.titleLong-Term endocrine outcomes with special emphasis on the gonadal impact of acute lymphoblastic leukemia treatment in females
dc.typeArticle
dspace.entity.typePublication

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