Development of lipid nanoparticles for transdermal loteprednol etabonate delivery

Basit Öğe Kaydı
dc.authorid0000-0001-6212-2706en_US
dc.authorscopusid57194855634en_US
dc.authorwosidP-2971-2019en_US
dc.contributor.authorÜner, Burcu
dc.contributor.authorÖzdemir, Samet
dc.contributor.authorTaş, Çetin
dc.contributor.authorÖzsoy, Yıldız
dc.contributor.authorÜner, Melike
dc.date.accessioned2022-05-24T06:19:31Z
dc.date.available2022-05-24T06:19:31Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Teknoloji Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractAim Loteprednol etabonate (LE) is a new generation corticosteroid that is used for the treatment of inflammatory and allergic conditions of the eye. Therefore, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were attempted to improve for transdermal LE delivery for the first time. Methods SLN and NLC were produced by hot homogenization and ultrasonication technique. Their physical stability was monitored for 3 months of storage. Drug release and permeation of SLN and NLC through the porcine skin were investigated. Results It was determined that SLN and NLC mean particle size as 139.1 nm had a homogeneous particle size distribution (∼0,169 PI) and mean charge as -23.6. They were found to be stable both physically and chemically at room temperature. Conclusion SLN and NLC formulations of LE can be stated among the systems that can be an alternative to conventional systems with less side-effect in the treatment of inflammatory problems.en_US
dc.identifier.citationÜner, B., Özdemir, S., Taş, Ç., Özsoy, Y., & Üner, M.. (2022). Development of lipid nanoparticles for transdermal loteprednol etabonate delivery. Journal of Microencapsulation, 39(4), pp. 327-340. https://doi.org/10.1080/02652048.2022.2079744en_US
dc.identifier.doi10.1080/02652048.2022.2079744en_US
dc.identifier.endpage327en_US
dc.identifier.issue4en_US
dc.identifier.pmidPMID: 35583383en_US
dc.identifier.scopus2-s2.0-85131358899en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage340en_US
dc.identifier.urihttps://doi.org/10.1080/02652048.2022.2079744
dc.identifier.urihttps://hdl.handle.net/20.500.13055/218
dc.identifier.volume39en_US
dc.identifier.wosWOS:000804681800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorÖzdemir, Samet
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofJournal of Microencapsulationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLoteprednol Etabonateen_US
dc.subjectNanostructured Lipid Carriersen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectTopical Corticosteroidsen_US
dc.subjectTransdermal Deliveryen_US
dc.titleDevelopment of lipid nanoparticles for transdermal loteprednol etabonate deliveryen_US
dc.typeArticleen_US
dspace.entity.typePublication

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
Development of lipid nanoparticles for transdermal loteprednol etabonate delivery.pdf
Boyut:
2.01 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Kapalı Erişim
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Farmasötik Teknoloji Ana Bilim Dalı Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu