Aza-BODIPY photosensitizer substituted with phthalonitrile groups: Synthesis, photophysical properties and in vitro tests for breast cancer

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dc.authorid0000-0002-6424-7411en_US
dc.authorscopusid57366670900en_US
dc.contributor.authorÖzçelik, Şennur
dc.contributor.authorGök Yurttaş, Asiye
dc.contributor.authorKahveci, Muhammet U.
dc.contributor.authorSevim, Altuğ Mert
dc.contributor.authorGül, Ahmet
dc.date.accessioned2022-11-11T06:44:48Z
dc.date.available2022-11-11T06:44:48Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalıen_US
dc.descriptionTurkish Academy of Sciences (TUBA)en_US
dc.description.abstractIn photodynamic therapy (PDT), reactive oxygen species (ROS) are generated through dynamic interactions between light of a specific wavelength, a photosensitizer (PS) and molecular oxygen. Nowadays, there has been an increment in the number of studies evaluating the possible utilization of BF2 chelated tetraarylazadipyrromethanes (aza-BODIPYs) as photosensitizers in PDT. In this study, a novel aza-BODIPY with phthalonitrile substituents was synthesized by the esterification reaction of a phthalonitrile derivative namely, 4-((3,4-dicyanophenyl)sulphanyl)benzoic acid with an aza-BODIPY bearing hydroxy groups on the para positions of distal phenyl groups. Aza-BODIPY compound bearing phthalonitrile substituents was characterized by using UV-Vis, fluorescence, H-1-NMR and mass spectroscopy techniques. Photophysical and photochemical properties including fluorescence quantum yield and singlet oxygen yield were determined. In order to explore its photodynamic efficacy, it was tested on a breast cancer cell line (MCF-7 cells) and on a normal healthy cell line (L929 cells) through dark and light cytotoxicity. (c) 2022 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.identifier.citationÖzçelik, Ş., Gök Yurttaş, A., Kahveci, M. U., Sevim, A. M. & Gül, A. (2023). Aza-BODIPY photosensitizer substituted with phthalonitrile groups: Synthesis, photophysical properties and in vitro tests for breast cancer. Journal of Molecular Structure, 1271. https://doi.org/10.1016/j.molstruc.2022.134019%200022-2860en_US
dc.identifier.doi10.1016/j.molstruc.2022.134019en_US
dc.identifier.scopus2-s2.0-85137157990en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2022.134019%200022-2860
dc.identifier.urihttps://hdl.handle.net/20.500.13055/303
dc.identifier.volume1271en_US
dc.identifier.wosWOS:000859282600016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynak.otherSCI-E - Science Citation Index Expandeden_US
dc.institutionauthorGök Yurttaş, Asiye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAza-BODIPYen_US
dc.subjectPhthalonitrileen_US
dc.subjectPhotodynamic Therapy (PDT)en_US
dc.subjectDark Toxicityen_US
dc.subjectLight Toxicityen_US
dc.subjectCanceren_US
dc.subjectSynthesisen_US
dc.titleAza-BODIPY photosensitizer substituted with phthalonitrile groups: Synthesis, photophysical properties and in vitro tests for breast canceren_US
dc.typeArticleen_US
dspace.entity.typePublication

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